Postdoctoral positions funded by the NIH are available in the Moskowitz group at The University of Chicago (http://moskowitzlab.uchicago.edu/index.html). We are looking for applicants excited about combining life sciences and computation to analyze the gene regulatory principals of development, regeneration, health, and disease. The laboratory integrates genomics, bioinformatics, molecular biology, mouse genetics, human genetics, embryonic stem cell differentiations, RNA biology and single cell sequencing to investigate the molecular mechanisms of organ development, homeostasis, and disease. The group has developed novel approaches to investigate the control of organ progenitor maintenance versus differentiation and the gene regulatory networks controlling adult cardiac homeostasis and disease.
Position 1. Although many lineage-specific developmental regulators have been uncovered, the molecular mechanisms that control organ progenitor maintenance versus differentiation remain understudied. We have recently uncovered a generalizable molecular mechanism underlying progenitor maintenance and differentiation timing control (e.g.bioRxiv 736322; doi: https://doi.org/10.1101/736322). These mechanisms have implications for developmental defects, cancer, and adult organ degeneration and regeneration. The successful candidate will join our NIH funded investigation of the genomic and molecular analysis of differentiation control in diverse lineages.
Position 2. We have a productive history of investigating the gene regulatory principals controlling homeostasis of cardiac rhythm and function (https://stm.sciencemag.org/content/8/354/354ra115). We have pioneered a novel approach for identification of functional enhancers and associated non-coding RNAs (lncRNAs) (https://elifesciences.org/articles/31683. We are applying these approaches to understand the molecular mechanisms underlying cardiac arrhythmias and heart failure. This project will integrate human genetics, transcriptional regulation, and RNA biology, and will impact cardiovascular genetics and human molecular genetics more broadly.
The laboratory is located in the Knapp Center for Biological Discovery at the University of Chicago. We are affiliated with the Departments of Pediatrics, Pathology, and Human Genetics and the Institute for Genomics and Systems Biology (http://www.igsb.org) at the University of Chicago. We are also affiliated with graduate programs in Development, Regeneration and Stem Cell Biology
(https://drsb.uchicago.edu) and Genetics, Genomics and Systems Biology
(https://ggsb.uchicago.edu. Postdoctoral scholars will also be supported by the University of Chicago’s Postdoctoral Association.
We seek highly motivated individuals with a record of strong publications. Highly motivated candidates with a recent PhD in developmental biology, molecular biology, genetics, pathology, cardiology or related field and with at least one first author paper in an English language journal are encouraged to apply. Experience with genomics, molecular biology, mouse genetics, and/or bioinformatics is sought; molecular biology skills are essential.
Please send a letter describing research experience/interest, CV, and contact information for three references electronically to: email@example.com.
Please address correspondence to:
Ivan Moskowitz, M.D., Ph.D.
Professor and Vice Chair for Research
Departments of Pediatrics, Pathology, and Human Genetics
The University of Chicago
900 East 57th Street, KCBD Room 5102
Chicago, Illinois 60637
Key words: Differentiation, Genetics, single cell sequencing, Genomics, gene regulatory network, Heart, Development, Developmental Biology, regeneration, degeneration, Congenital Heart Disease, Cardiac, morphogenesis, cardiology, organogenesis, molecular mechanism
The University of Chicago is an Affirmative Action/Equal Opportunity Employer.