Icahn School of Medicine at Mount Sinai (ISMMS), MSHS

Postdoctoral Researchers in Solid Tumor Immunology and Cellular Immunotherapy

Icahn School of Medicine at Mount Sinai (ISMMS), MSHS

New York, NY, United States

The Challenge: Chimeric antigen receptor (CAR) T cell therapy/adoptive cell therapy involves the transfer of hundreds of millions of tumor-specific T cells into a patient, some of which traffic to the tumor site where they interact with target as well as nontarget cells that comprise the immune tumor microenvironment (TME). High-dimensional approaches have mapped out the immune TME of solid tumors with unprecedented detail and scope, identifying novel cell types and states that can dramatically alter the activity of cytotoxic T cells. To advance CAR T cell therapy for solid tumors, we need to discover how to manipulate CAR T cell interactions within the TME to enhance tumor killing and CAR T cell persistence.

Description: The Ahmed Khan lab is part of the highly collaborative and interdisciplinary Precision Immunology Institute and the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai in Manhattan. We are recruiting energetic and motivated postdoctoral researchers in immunology and immunotherapy to join our team. Postdoctoral researches will use immunocompetent tumor models to understand the parameters driving CAR T cell activity and fate within the TME, and design novel CAR T cell therapies that capitalize on the immunobiology of solid tumors to achieve durable anti-tumor responses.

Institute Description: The Precision Immunology Institute at Mount Sinai (PrIISM) and the Tisch Cancer Institute (an NCI-designated Cancer center) initiated the Cancer Immunology Program at Mount Sinai to advance biomedical research and science education towards the betterment of patients afflicted with cancer. We empower exceptional scientists and students to use state-of-the-art technologies to pursue fundamental questions in emerging areas of cancer immunotherapy and anti-tumor immunity. PrIISM and the TCI are closely associated with the Icahn School of Medicine and Hospital network that serves patients in New York City and the Tristate area. To learn more, visit: https://icahn.mssm.edu/research/immunology/research/cancerimmunology and https://careers.mountsinai.org/explore-mount-sinai.

Your qualifications: Candidates must have graduate level training (MD or PhD) in Medicine, Oncology, Immunology, Bioengineering or related fields and ideally have extensive knowledge and experience working with mouse models, and molecular/cell biology methods.


Positions & Availability: 2 Openings available immediately.

Contact: Interested applicants should send a cover letter and CV to: jakradonc@gmail.com.

Mount Sinai is an Equal Opportunity Employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.

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Postdoctoral Researchers in Solid Tumor Immunology and Cellular Immunotherapy