Yale University

Postdoctoral researcher

Yale University

New Haven, United States

We are looking for a talented senior postdoctoral fellow with background in cell biology and very good publication record to join our team. We conduct translational research in multiple sclerosis (MS) with the goal of understanding the mechanisms that underlie MS progression and neurodegeneration.

The candidate will participate in our larger effort to examine how genetic risk variants dysregulate glial cell function in MS and Alzheimer disease (Ponath et al. Nature Comm. 2018), and to identify cellular subpopulations and their interactome in chronic and remyelinating MS lesions (Park et al. Acta Neuropath Comm. 2019).

Our laboratory uses cutting-edge technologies such as generation of human iPSC-derived astrocytes and microglia, highly multiplexed histological imaging (staining of individual section with 40+ antibodies), advanced computational tools for spatial analysis, and purification of astrocyte and oligodendrocyte nuclei from MS, Alzheimer and Parkinson tissue for transcriptomic and genomic profiling with sNuc-Seq and ATAC-Seq.

Our laboratory is part of the Department of Neurology, Yale School of Medicine, and is embedded in a highly collaborative, translational neuroimmunology program that includes T cell biology, genetics and computational biology. 

The candidate should have a broad neurobiology background and experience with cell-based assays in primary cultures. Expertise in generating and differentiating of iPSCs into CNS cells is desirable. Please respond with CV, a short description of relevant expertise, representative publications and the names of three references by email to david.pitt@yale.edu. The successful candidate will join the Department of Neurology for a minimum of 2 years with possible extension.

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Position

Postdoctoral researcher