Karolinska Institutet (KI)

Postdoctoral researcher to work on Chaperone-Mediated Autophagy

Karolinska Institutet (KI)

Solna, Sweden

At the Department of Physiology and Pharmacology we teach and conduct internationally acclaimed, high-quality research in Physiology, Pharmacology, Anesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students. Our research fields include cellular signaling, cardiovascular and respiratory systems, neuropsychopharmacology, neuroinflammation, pharmacogenetics, regenerative medicine, Renal System, anesthesiology and intensive care, muscle physiology and pain. Our collaboration with the clinics at Karolinska University Hospital provides unique opportunities for translational research within our subjects. More information about research at http://ki.se/fyfa_english

Division
One postdoctoral position is available in the Research Group of Protein Degradation Pathways at the Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet.

The group focuses on Autophagy (in particular CMA). By studying these pathways, previous studies from the group uncovered that CMA can selectively be directed to target oncoproteins (proteins involved in the onset or development of cancers) (Hao et al., Autophagy, 2019; Xia et al., JCB 2015). In addition, specific targeting to UPS is also investigated in the group (Eriksson et al., MCB, 2017; Zhang et al., Cell Reports, 2017). Currently, the group is interested in investigating the CMA pathway in depths both at cellular and organismal level, in order to explore the role of CMA in various human disorders. The study will involve integrative approaches consisting of cell biology, tanscriptomics, bioinformatics, genetic, biochemical and molecular biological tools using in cancer and normal cells and mice tissues.  

Duties
The applicant will conduct research within the field of molecular cancer research and cell biology with a focus on Autophagy pathways. The Postdoc candidate will be expected:

  • to work independently or in a team.
  • to possess an ability to develop and create ideas and hypothesis,
  • to carry out scientific methodology and analysis,
  • to experimental design, project coordination, daily project operation,
  • to perform trouble shouting and improvement of experiments,
  • to co-write scientific papers and grant applications,
  • to read and discuss recent literature
  • to attend and present at group meetings,
  • To have the primary responsibility for the development of his or her project.

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Other requirements

We seek a highly motivated, dedicated and hardworking individual with previous experience in cell and molecular biology as well as biochemistry in Autophagy and cancer biology fields.

The candidate must have a Ph.D. in Medical Sciences or related discipline(s). Candidate who have experience with cancer research and possess a strong background in cancer biology and Autophagy will be priorities for interviews. Candidates with extensive and documented experience in tumor biology, cellular protein degradation pathways are urged to apply. Candidates that possess previous work and publications on autophagy, chaperone-mediated autophagy and the Ubiquitin proteasome system (UPS) are favorable.

The candidate must be willing to work ambitiously and effectively in a collaborative environment with a strong commitment to research. The successful candidate must have strong organizational skills with the ability to manage several projects simultaneously. A great ability to express themselves in speech and writing, including scientific writing in advanced level of English are required. The candidate´s personal skills will be highly valued and emphasis will be placed on personal skills, knowledge and abilities, as well as on documented previous work. The ideal candidate should have published first author publications from previous work.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Please apply via recruiter’s website.

Quote Reference: 303153

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