The University of Texas Southwestern Medical Center (UT Southwestern Medical Center)

Postdoctoral Researcher

Children's Research Institute at UT Southwestern Medical Center

Dallas, TX, United States

Postdoctoral positions in Nutrient Signaling – Hoxhaj Lab

Postdoctoral positions for highly motivated research fellows are available in the laboratory of Dr. Gerta Hoxhaj to study metabolite and nutrient sensing by signaling pathways. Dr. Hoxhaj is an Assistant Professor at the Children’s Medical Center Research Institute, UTSW, Dallas, USA. Further information about research in Hoxhaj lab can be found at:

(https://cri.utsw.edu/scientists/gerta-hoxhaj-laboratory/).

 Dr. Hoxhaj’s previous studies have uncovered key intersections between cellular signaling and metabolism.

  • Discovery of de novo purine synthesis as a novel metabolic program downstream of mTORC1 signaling (Ben-Sahra I*, Hoxhaj G*, et al., 2016, Science).  
  • mTORC1 signaling network senses purine nucleotide levels (Hoxhaj et al., 2017, Cell Reports).
  • Controls of the cellular reducing power NADP through Akt-mediated phosphorylation of NAD Kinase (Hoxhaj*, et al., 2019, Science).


Research in the Hoxhaj Lab focuses on understanding the molecular mechanisms that control cellular metabolism in the context of cancer, metabolic disorders and aging. We are seeking highly bright and enthusiastic scientists that are interested in understanding how metabolic outputs and nutrient availability are coordinated with signaling networks to sustain cellular homeostasis and investigate the consequences when this coordination is lost in disease. 

 

Candidates must hold a Ph.D. or M.D/Ph.D. degree. Research background in biochemistry, molecular biology, cell biology are preferred. The successful candidates will have access to state-of-the-art technologies in metabolomics, biochemistry, proteomics, cell biology and mouse models in an excellent and dynamic academic environment. Interested applicants should submit a CV, a brief description of their research achievements and interests, the name and contact details for three referees to gerta.hoxhaj@utsouthwestern.edu.

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Position

Postdoctoral Researcher