University Medical Center Hamburg-Eppendorf (UKE), UHH

Postdoctoral Researcher (m/f/d) - Vascular Biology

University Medical Center Hamburg-Eppendorf (UKE), UHH

Hamburg, Germany

We are the University Medical Center Hamburg-Eppendorf (UKE), a vibrant research and healthcare community right at the heart of Hamburg. There is a real buzz of energy here, as progress sets the pace and every day offers fresh experiences. Around 11,000 members of staff with a huge diversity of roles are united in pursuit of a single aim: human wellbeing. With more than 140 different professions, we are the ideal place for anyone who loves to work in a flexible environment, for anyone ambitious to advance their own personal development and that of healthcare as a whole.

What we can offer

  • An innovative, family-friendly working environment right in the middle of Hamburg (day nursery, free child care during the school holidays)
  • Opportunity to participate in a wide range of vocational training, continuing and further education courses at the UKE Academy for Education and Careers, as well as a broad spectrum of introductory events
  • An attractive company pension scheme and the use of diverse and multiple award-winning health and illness-prevention offers

What to expect
The young and motivated research group Vascular Biology studies the impact of extracellular matrix stiffness (ECM stiffness) on the behavior of endothelial cells during vascular morphogenesis and disease.
The project aims to identify and characterize novel ECM stiffness-regulated genes in endothelial cells, with a focus on cell-matrix adhesion, cell-cell adhesion and endothelial contact regulation. Our research group employs a variety of transgenic mouse models, primary cell culture systems and state-of-the-art microscopy methods such as live imaging, super-resolution and atomic force microscopy (AFM).
The research group Vascular Biology is part of the Institute for Clinical Chemistry and Laboratory Medicine under the direction of Prof. Dr. med. Dr. Thomas Renne as a leading international expert in the field of vascular inflammation and thrombosis research.

Main techniques used in this project:

  • Generation and characterization of transgenic mice
  • Isolation and culture of primary endothelial cells, adenoviral and lentiviral gene expression in endothelial cells
  • qPCR analysis and Western blot analysis
  • Whole mount immunofluorescence staining and confocal microscopy
  • Quantification of imaging data, quality control, large datasets and statistical analysis
  • Planning of experiments, preparation and participation in scientific publications and congress participation

What we look for in a candidate (m/f/d)

  • PhD degree in biology, biochemistry, biophysics or related subject
  • A strong track record with peer-reviewed publications
  • In-depth interest in vascular biology, endothelial cell biology and mechanobiology
  • Desirable are experiences in endothelial cell biology, developmental biology or mechanobiology, experimental animal work (FELASA course), and applied laboratory methods: primary cell culture, 2D matrix gel preparation, qPCR, advanced fluorescence microscopy and atomic force microscopy.
  • Adobe Illustrator, lmageJ, and GraphPad Prism knowledge
  • Ability to work independently, organizational skills, teamwork, quick comprehension, commitment

Contact:
Dr. Maike Frye, Group Leader, e-mail: m.frye@uke.de
We look forward to receiving your completed application by 16th of December stating reference code 2019-784 on our online portal.

Please apply via recruiter’s website.

Quote Reference: 2019-784

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