Do you want to contribute to top quality medical research?
A 2-year postdoctoral position to study the role of global transcription factor activity in cellular lineage determination is available immediately in the laboratory of Professor Jussi Taipale who heads research groups at Karolinska Institutet, University of Cambridge and University of Helsinki. This position is funded by the Swedish Foundation for Strategic Research and is based at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet (https://ki.se/en/mbb/jussi-taipale-group).
The laboratory focuses on the study of transcriptional control of cell growth, using functional genomics and systems biology and as such the research groups consist of both experimental biologists and computer scientists. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, using this information to identify regulatory elements that control cell growth during normal development or in cancer and validation of identified elements in cultured cells and mouse genetic models (see for example Hallikas et al., Cell 124:47-59, 2006; Kivioja et al., Nature Methods 9:72-74, 2011; Sur et al., Science 338:1360-1363, 2012; Jolma et al., Cell 152:327-339, 2013; Yan et al., Cell 154:801-813, 2013; Jolma et al., Nature 527:384-388, 2015; Yin et al., Science 356: eaaj2239, 2017; Zhu et al., Nature 562: 76-81, 2018). The applicant benefits greatly from knowledge and expertise of a lab working at the cutting edge of science.Your mission
The goal of the project is to apply the ATI technique developed in the lab (Wei et al., Nature Biotechnology 36: 521-529, 2018) to build a repertoire of critical TFs that specify different cell fates and use this information for trans-differentiation of cells. The project requires that the applicant has excellent skills in lab work as well as computer programming (primarily Python, Perl and R).Your profile
The successful candidate should be highly motivated and have a doctoral degree or a foreign qualification deemed equivalent to a doctorate in Systems Biology, Molecular Biology, Biological engineering, Medicine or similar along with computational experience for analysing large sets of data. We especially encourage applications from those who expect to complete their PhD within one year from current date and those who have completed their PhD less than 12 months ago. Applicants must be able to work independently and have good communication skills in English.What do we offer?
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.
Location: Solna, BiomedicumApplication
An employment application should be a maximum of 7A4 pages in total and must contain the following documents in English:
- One-page cover letter highlighting your 2 most important first-author publications in major international scientific journals
- Two-page CV including a list of major publications (reference only, no abstracts or full papers)
- Two letters of recommendation, 1-2 pages each
Welcome to apply at the latest 2020-03-15
The application is to be submitted through the Varbi recruitment system.Want to make a difference? Join us and contribute to better health for all