Postdoctoral research position at Rosalind Franklin University of Medicine and Science-The Chicago Medical School in the Center for Stem Cell and Regenerative Medicine and the Center for Neurodegenerative Diseases and Therapeutics.
These Centers are seeking a talented and highly motivated candidate to conduct independent neuroscience research in the laboratory of Dr. Daniel A. Peterson (Regenerative Medicine) in collaboration with Dr. Grace E. Stutzmann (Alzheimer’s Disease).
The research focus will be related to in vivo neuronal reprogramming and the morphological and functional integration of newly reprogrammed neurons on a background of Alzheimer’s disease. This position will directly support preclinical studies to develop new therapies. This project is NIH-funded. The postdoctoral fellow should have a background and interest in neural stem cell biology, therapeutic approaches including gene therapy, neurodegenerative diseases including Alzheimer’s disease, and cellular and molecular neuroscience.
Primary responsibilities are to conduct morphological and functional imaging experiments in brain slice and in vivo preparations in rodents, and in iPSCs from human samples and other cultured cell models. Imaging will be conducted by resonance scanning confocal and multiphoton microscopy and light sheet microscopy with quantitative analysis using stereology and artificial intelligence. Functional analysis will include whole cell patch and field potential electrophysiology and calcium imaging modalities in brain slice and cell culture preparations.
· Designing and performing in vitro and in vivo studies on reprogramming glia to neuronal lineages
· Investigating mechanisms of neuronal lineage determination, subtype specification, and function
· Generation and maintenance of stem/progenitor cell cultures
· Participation in molecular cloning, viral vector production, and gene delivery studies
· Rodent (mouse and rat) surgical procedures including stereotaxic brain surgery
· Histological sample preparation, immunofluorescence staining, and quantitative microscopic analysis by confocal microscopy
· Production of brain slice and cell culture samples for functional analysis
· Performance of calcium imaging and electrophysiological studies
· Data analysis, manuscript/grant preparation and writing associated with the project
· Mentoring/teaching techniques to qualified students and technicians.
Experience and Expertise:
· Ph.D in neuroscience or stem cell-related discipline (awarded or pending)
· Demonstrated productivity and strong publication record
· Demonstrated expertise in rodent surgical procedures including stereotaxic surgery and transcardial perfusion
· Demonstrated expertise in histological sample preparation for multiple fluorescence labeling and confocal microscopy
· Demonstrated expertise in electrophysiological recording using whole cell patch clamp and field potentials in brain slices
· Ability to collect and analyze data and experience in statistical analysis
· Excellent organizational and planning skills
· Excellent English reading, writing and verbal communication skills
· Ability to work independently and as part of a team
· Demonstrated project management skills, including ability to set priorities and excellent time management skills
· Ability to work productively with diverse populations; show respect and sensitivity for cultural differences
Learn more about our teams:
How to apply:
Review of applications will begin immediately and will continue until the position is filled. Qualified applicants are encouraged to apply via Rosalind Franklin University of Medicine and Science Career opportunities at: