We are seeking a highly-motivated post-doctoral research scholar to join the Singh Lab in our effort to identify the mechanisms underlying failure of adoptive cellular immunotherapies. The Singh Lab studies how chimeric antigen receptors (CARs) direct functional and dysfunctional T cell biology in the treatment of cancer. We are specifically interested in elucidating how interactions between CAR T cells and cancers result in the initiation and maintenance of biological pathways that drive T cell dysfunction. Our overall goal is to translate these discoveries using cutting-edge cellular engineering platforms to design improved, more effective cell therapies for cancer.
Through this post-doctoral experience, the researcher will have the opportunity gain or further develop expertise in immune cell signaling, proteomics, and single cell profiling of transcription and epigenetic regulation. The work in our laboratory consists of a mix of in vitro models and analysis of clinical samples from patients undergoing CAR T cell therapy. We work collaboratively with several researchers on and off campus, providing an opportunity for national and international networking.
The ideal candidate will have experience in human immunology, genome engineering and molecular biology. While not required, a background in bio-informatics analysis is highly encouraged. The candidate should be equipped to function independently, and bring a curious and innovative approach to drive the project forward. Additionally, the candidate should be interested in writing grants and research manuscripts, as well as presenting data on campus and at national meetings.