University of Luxembourg

Postdoctoral researcher focusing on the role of the human microbiome in chronic diseases

UNiversity of Luxembourg

Luxembourg, Luxembourg

The University of Luxembourg is a multilingual, international research University.

The University of Luxembourg has the following vacancy at the Luxembourg Centre for Systems Biomedicine (LCSB) as part of a recently funded European Research Council (ERC) Consolidator grant (https://erc.europa.eu/funding/consolidator-grants):

Postdoctoral researcher focusing on the role of the human microbiome in chronic diseases

Area: Multi-omic analyses of the gut microbiome secretome

The human gut microbiome is a complex ecosystem which contributes essential functions to human physiology. Changes to the microbiome are associated with several chronic diseases characterised by inflammatory signatures including autoimmune and neurodegenerative diseases. The gut microbiome produces a complex secretome comprised of soluble nucleic acids, (poly-)peptides and metabolites with bioactive properties, which have so far eluded in-depth study. This gap in knowledge is limiting our understanding of the role of the human microbiome in governing human physiology and how changes to the gut microbiome impact inflammation-linked chronic diseases such as rheumatoid arthritis (RA) and Parkinson’s disease (PD). As part of the ERC-funded ExpoBiome project, a quantitative integrated multi-omic analysis (metagenomics, metatranscriptomics, metaproteomics and metabolomics) will be performed on gut microbiome samples collected from healthy human individuals and patients newly diagnosed with RA or PD. Using the cross-sectional data, extracellular microbial molecules will be identified, which are particularly enriched in, depleted in or common to the respective diseases, and traced to their respective microbial populations of origin. The resulting molecular signatures will be used to populate a dedicated Knowledge Base and to develop microbiome-based diagnostic classifiers for RA and PD.

Your Role

You will define the gut microbiome secretome in the context of two chronic diseases (PD and RA), compared to healthy individuals, and relate this information to the immunophenotypes of the individuals. Based on the generated data, you will develop microbiome-based diagnostic classifiers for RA and PD. You will contribute to populating the ExpoBiome Knowledge Base (http://expobiome.lcsb.uni.lu).

For further information, please contact: Prof. Dr. Paul Wilmes, paul.wilmes@uni.lu

Telephone: (+352) 46 66 44 6188

Your Profile

  • A researcher with PhD, who is in the first four years (full-time equivalent research experience) of her/his research career, measured from the date when she/he obtained her doctoral degree
  • You will have experience in bioinformatics, modelling and/or high-throughput biomolecular analytics. Experience in bioinformatics, computational biology, or related fields
  • Knowledge of coding and complex data analysis is an absolute must
  • Well-structured and autonomous working style, good organizational and communication skills
  • Fluency in written and spoken English is a must, German and/or French is a plus

We offer

Fully funded PhD position as part of an ERC Consolidator grant. The opportunity to work as part of an international, interdisciplinary team. The University offers competitive salaries and is an equal opportunity employer.

Further Information

The postdoctoral researcher will work in the Eco-Systems Biology group at the LCSB and will be supervised by the head of the group, Prof. Dr. Paul Wilmes.

Advertised until filled.

Please apply via recruiter’s website.