A position is available for an outstanding postdoctoral researcher to study the fundamental control of lymphatic vascular or neurovascular cell lineages in the context of embryonic development and models of cancer. The position is available in the Hogan Laboratory at the Peter MacCallum Cancer Centre and the University of Melbourne, Australia.
The candidate will use developmental genetics, cell biology and molecular biology approaches to study the formation of new vasculature lineages. There will be an emphasis on the lymphatics and perivascular microenvironment in relation to embryonic development and cancer. The candidate will investigate fundamental aspects of cell fate determination, cell function and cell-cell communication using model organisms and human cells. The candidate will conduct their own focussed research projects, contribute to large team-driven projects and will be involved in the training of undergraduate and postgraduate students. The candidate should hold a PhD and have experience in genetics, cell biology and molecular biology. The candidate will work closely embedded with embryologists, developmental and cell biologists in a team environment within the Hogan group and the Program in Organogenesis and Cancer at Petermac
The Hogan laboratory uses zebrafish and mouse model systems to characterise developmental mechanisms of lymphatic vascular development and the function of perivascular lineages at the blood brain barrier. Lymphatic vessels are important in tissue fluid homeostasis, immune cell function and metastasis. The blood brain barrier (BBB) separates the brain parenchyma from circulating blood and macromolecules, representing a significant challenge for delivery of cancer therapeutics, and acting as a barrier in metastasis. The successful applicant will have the opportunity to develop their research project in these key areas, utilising the zebrafish, mouse models and human cell-based systems. For further information on specific project themes, contact Prof Ben Hogan.
The successful applicant will apply molecular genetics, genomics, bioinformatics, biochemical approaches and live imaging of cellular behaviours. As part of an integrated team, the postdoc will contribute to a large scale forward genetic screen using zebrafish and develop their own research niche.
For further details see the Hogan laboratory website or contact Prof Ben Hogan.
Essential: PhD in genetics or molecular biology
Desirable: Experience in training staff and/or students
Desirable: Experience in confocal imaging of cells and tissues
Desirable: Experience in model organism genetics
Desirable: Developmental Biology experience or zebrafish research experience
Desirable: Experience in attracting competitive research funding
Remuneration for the role will be in line with the Allied Health Professionals (Victorian Public Health Sector) Single Interest Enterprise Agreement 2016-2020 - classification 1RA6 to 1RA10 based on qualifications and experience.