A post-doctoral researcher position is now available in the team of Dr. G. Ichim at the CRCL (http://www.crcl.fr/704-Cancer-Cell-Death-en-GB.crcl.aspx?language=en-GB) located in Lyon, France. The main focus of the team is studying mitochondrial regulation of cell death and non-lethal caspase activation with a wide-range of implication in cancer cell invasiveness, resistance to therapy or cancer stem cells.
Apoptosis (a form of programmed cell death) is the driving force behind the morphogenesis of all organisms, with millions of cells dying each second. This impacts on the normal function of our immune system or brain development. It acts also as a strong tumour suppressive mechanism since it prevents cancer initiation and progression. Mitochondria are organelles that orchestrate apoptosis through an event called mitochondrial outer-membrane permeabilisation (or MOMP) that is responsible for caspase activation and eventually rapid cell death.
Our lab is driven by fundamental questions about mitochondria and caspase function in both physiological and cancer context (Berthenet et al., 2019, BioRxiv, doi.org/10.1101/755744, Roumane et al., 2018, BMC Cell Biology, Ichim and Tait, 2016, Nat Rev Cancer; Ichim et al., 2015, Mol Cell). Using state-of-the-art microscopy and intra-vital imaging the postdoctoral researcher will tackle two projects:
- Define the role of mitochondrial dynamics in breast cancer cells migration and invasion;
- Setting up genetic reporters allowing visualisation of apoptosis in vivo.
More information about the institute can be found online (http://www.crcl.fr).
We are looking for highly motivated, enthusiastic and interactive candidates (PhD degree or equivalent) with experience in cell biology, biochemistry and eventually in vivomouse work. Candidates with experience in advanced microscopy and/or mitochondrial biology are particularly encouraged to apply. Good communication skills in English are important and knowledge of French is not required. The candidate should also be able to work as part of a team, while having a strong problem-solving attitude. Applying for external funding (EMBO, Marie Curie, ARC, etc.) will be highly recommended. Salary support is commensurate with experience.
Conditions of the postdoctoral contract
Institutional-funded position renewable once a year, for up to 3 years. Starting date: mid 2020.
Please submit your CV, motivation letter, the names of 2-3 references and a list of publications to email@example.com(indicate POSTDOC 2020in the mail title).