Postdoctoral Research Scientist
Fixed-Term, 3 years
£35,859 – £38,700 pa inclusive*
The Chromatin & Development group, led by Dr Michelle Percharde, focuses on understanding the molecular events surrounding cell fate choices during early development. We aim to dissect novel transcriptional, epigenetic, and signalling axes important for embryogenesis. Visit www.perchardelab.com and https://lms.mrc.ac.uk/research-group/chromatin-and-development/ for more information.
Based on our recent research, a particular focus of the lab and of the role is to uncover how retrotransposons have been co-opted to regulate the earliest stages of mammalian development. You will use mouse and human embryonic stem cells (ESCs) and mouse embryos as models, adopting a combination of genome-wide techniques, CRISPR/Cas9 technology, high-resolution microscopy, biochemistry and molecular embryology approaches to probe gene and transposon function. You will be a key member of the Chromatin & Development group, and as such will enjoy a high level of scientific responsibility. You should have a strong background in chromatin, gene regulation and/or early development, and you will be expected to be proactive in developing your research question within the group’s areas of interest and expertise.
You will need:
• A PhD degree in a relevant biochemical/biological/biomedical discipline (or be in the final stages of completing one or equivalent experience):
• Significant experience working with mammalian systems (e.g., tissue culture)
• Extensive practical experience in molecular biology techniques
• A strong conceptual background and interest in one of the following: mammalian epigenetics, development, gene regulation or transposable element biology
This is an MRC Postdoctoral Scientist position providing training and development supporting post-doctoral scientists in early or changed career paths helping establish them as successful research scientists in their chosen field.
The MRC London Institute of Medical Sciences is a research institute within UK Research and
Innovation. UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org
Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.
For full details of this post (Job Description and Person Specification) and to complete an online application, visit https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/1338 and upload your CV, the names and contacts of two scientific references, along with a cover letter stating why you are applying for this post (providing evidence against the requirements as per the Job Description and Person Specification) quoting reference LMS 1199.
Salary quoted is inclusive of London weighting. Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.