CRUK Beatson Institute for Cancer Research

Postdoctoral Research Scientist

The Cancer Research UK Beatson Institute

Glasgow, Scotland, United Kingdom

Postdoctoral Research Scientist

How the interplay between metabolism and epigenetics controls CAF functions in breast cancer

Prof Sara Zanivan

Starting Salary from £31,604 to £43,788 (Depending on experience) plus relocation allowance where appropriate. Three year fixed term contract funded by Breast Cancer Now.

Would you like to develop your scientific career in a research institute that is founded on the quality of its people, acknowledged for its collaborative environment and designed to promote the development of the most outstanding and dedicated scientists? Many early career researchers have already made that decision and at present over 100 of them are now benefiting from our excellent training programme.

The Cancer Research UK Beatson Institute supports cutting edge research into the molecular mechanisms of cancer development and is one of the leading research institutes in Europe. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies, with special emphasis on imaging, metabolomics, proteomics and in vivo models.

Our innovative and ambitious research themes focus on understanding the regulation of the tumour microenvironment and cancer metabolism, in particular:

Intrinsic cancer cell vulnerabilities
Interplay between the tumour microenvironment, metastasis and recurrence
Biology of early disease, aimed at developing a ‘Precision Prevention’ approach

A postdoctoral position is available in the Tumour Microenvironment & Proteomics group headed by Professor Sara Zanivan. The group is a growing and vibrant team which aims to understand the role of cancer-associated fibroblasts (CAFs) in tumour invasion and metastatic spread. Our overarching goal is to find ways to target CAFs to improve the efficacy of therapeutic treatments in breast and ovarian cancers. This post will study the role that the interplay between metabolism and epigenetics in CAFs has in generating a pro-invasive and pro-metastatic tumour microenvironment in triple negative breast cancer. To achieve that, we will use cell biology, state-of-the-art metabolomics and proteomics, and genetically modified in vivo models.

Applicants must have a PhD in a relevant field, be ambitious and driven by scientific curiosity. Previous experience with regard to cell metabolism and/or epigenetics is required, and experience or interest in CAFs and in vivo cancer models would be an advantage.

To find out more about this unique opportunity to establish advanced skills and expertise in this exciting field please contact: Professor Sara Zanivan

The Cancer Research UK Beatson Institute is committed to increase the number of female scientists at this level and encourages female applicants to apply. We have recently introduced a highly attractive maternity policy which provides 12-18 months support and funding for postdocs wishing to take time off to spend with their children.

All applications must be made via our website at

Closing date for applications is 7 February 2020

Please apply via recruiter’s website.