Columbia University Medical Center (CUMC), CU

Postdoctoral Research Scientist

Columbia University Medical Center (CUMC), CU

New York, NY, United States

Postdoctoral Research Scientist

Columbia University’s Department of Medicine invites applications for a research position in the rank of Postdoctoral Research Scientist at The Columbia University Irving Medical Center in the Division of Molecular Medicine (Alan Tall, Director). The position includes both laboratory and translational research.

The Tall laboratory is conducting research on the pathogenesis of metabolic diseases including atherosclerosis and fatty liver. A major goal of research is to use information derived from human genetic studies to identify novel genes and pathways involved in disease pathogenesis. This has led to the discovery that mutations in genes that cause hematological malignancies also promote atherosclerosis in mouse models and in humans. As people age they commonly acquire such mutations (called clonal hematopoiesis of indeterminate potential or CHIP): this increases their risk of developing hematological malignancies but also atherosclerosis, diabetes, and possibly Covid-19. We are conducting research to elucidate the underlying cellular and molecular mechanisms which include excessive proliferation of hematopoietic stem cells, increased myelopoiesis and platelet production, platelet activation and macrophage inflammatory processes including inflammasome activation. An important goal is to use mechanistic discoveries to elucidate new therapeutic principles for treating human metabolic diseases.

References

1. Fidler TP et al, The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis, Nature, in press, 2021. 2. Hidalgo A, Tall AR. Leducq Transatlantic Network on Clonal Hematopoiesis and Atherosclerosis. Circ Res. 2019 Feb 15;124(4):481-483. PMID: 30763212.

3. Westerterp M et al. Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis. Circulation. 2018 Aug 28;138(9):898-912. PMID: 29588315

4. Tall AR, Levine RL. Cardiovascular disease: Commonality with cancer. Nature. 2017 Mar 2;543(7643):45-47. PMID: 28225756.

Required documents Curriculum Vitae Cover Letter Dissertation Abstract List of References Writing Sample/Publication 1 Writing Sample/Publication 2 Research Abstract

Contacts: Dr. Alan Tall art1@cumc.columbia.edu

Ms. Lilian A. Oling lao2106@cumc.columbia.edu

Apply with CV and Cover Letter

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Position

Postdoctoral Research Scientist