Columbia University’s Department of Medicine invites applications for a research position in the rank of Postdoctoral Research Scientist at The Columbia University Irving Medical Center in the Division of Molecular Medicine (Alan Tall, Director). The position includes both laboratory and translational research.
The Tall laboratory is conducting research on the mechanisms and treatment of atherosclerotic cardiovascular diseases. A major strategy is to use information derived from human genetic studies to identify novel genes and pathways involved in disease pathogenesis, then to use mechanistic insights to identify new treatments for human cardiovascular disease. Recent discoveries show that mutations in genes that promote hematopoietic stem cell fitness and predispose to hematological malignancies also much more commonly promote athero-thrombotic cardiovascular diseases. As people age they commonly acquire such mutations (called clonal hematopoiesis of indeterminate potential or CHIP) and have increased risk of developing atherosclerosis, thrombosis and heart failure. We are conducting research to elucidate the cellular and molecular mechanisms linking CHIP to atherosclerosis and thrombosis, including macrophage inflammasome activation, and inflammatory cross-talk from mutant macrophages to wild type macrophages, neutrophils and smooth muscle cells within atherosclerotic plaques.
References 1. Fidler TP et al, The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis, Nature, 2021, PMID 33731931. 2. Dou H et al, Oxidized phospholipids promote NETosis and arterial thrombosis in LNK deficiency, Circulation, 2021, PMID: 34846914
3. Westerterp M et al, Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis. Circulation. 2018 PMID: 29588315
4. Tall AR, Levine RL. Cardiovascular disease: Commonality with cancer. Nature. 2017 PMID: 28225756.
Required documents Curriculum Vitae Cover Letter Dissertation Abstract List of References Writing Sample/Publication 1 Writing Sample/Publication 2 Research Abstract
Contacts: Dr. Alan Tall firstname.lastname@example.org
Ms. Lilian A. Oling email@example.com