A postdoctoral position is available in the laboratory of Dr. Stephen Oh at Washington University School of Medicine in St. Louis, MO.
Our overarching objective is to decipher fundamental mechanisms that drive the initiation, development, and progression of hematologic malignancies. We study myeloproliferative neoplasms (MPNs), which are clonal disorders typified by genetic alterations that activate JAK-STAT signaling. We utilize innovative single cell technologies including mass cytometry (CyTOF) and single cell RNA sequencing to interrogate dysregulated cytokine signaling networks in MPNs. Potential projects may also utilize multiplex imaging technologies such as imaging mass cytometry and/or CODEX, which couple high dimensional single cell analysis with spatial localization.
We utilize human patient samples as well as mouse models to interrogate altered signaling pathways in MPN pathogenesis. A major area of interest in the lab is to utilize genetic models to understand the role of inflammatory cytokine signaling in MPNs. A second area of interest is the application of next generation sequencing technologies to delineate genomic complexity and clonal evolution in MPNs. We also utilize patient-derived iPSC and ES cell lines in conjunction with CRISPR gene editing to precisely model human MPN pathogenesis. The long-term objective is to integrate these approaches so that phenotype can be connected to underlying genotype. Ultimately, we seek to translate this work into improved therapies for MPN patients.
Applicants interested in cancer biology, signal transduction, genomics, immunology, hematopoiesis, leukemia, and/or stem cells are encouraged to apply.
Please see the following links for additional information:
Funding through a NIH T32 training grant is available for eligible candidates.
Applicants must have a Ph.D. and/or M.D. degree and a strong background in cell and molecular biology. Prior experience with flow cytometry, bioinformatics, genomics, and/or mouse models is highly desirable. Strong written and verbal communications skills are essential.
Please send an inquiry and C.V. with list of references to Dr. Oh at firstname.lastname@example.org.