DNA nanotechnology for single-molecule imaging of T cell receptor signalling
We are seeking an exceptional candidate for a postdoctoral position in single-molecule imaging to better understand how antigen binding to the T cell receptor (TCR) induces intracellular signals on which T cell fate decisions are based.
We aim to establish multiplexed single-molecule localisation microscopy (SMLM) via DNA-PAINT and automated and unsupervised data acquisition and analysis. The project includes the development of DNA origami structures for spatially controlled antigen presentation. Specifically, we aim to determine whether different spatial organisations of the antigen and the TCR induce distinct signalling pathways. These data will allow us to conceptualise how a common signal transduction unit induces signalling along different pathways upon binding of the same antigen.
The successful candidates will join our multi-disciplinary team of Cell Biologists and Biophysicists at the EMBL Australia Node in Single Molecule Science, University of New South Wales, Sydney, Australia (sms.unsw.edu.au) and the ARC Centre of Excellence in Advanced Molecular Imaging (ImagingCoE.org). Postdoctoral researchers will have an active role in conceiving and implementing approaches, training and supervision of research staff and students, and reporting of the results in the form of publications, international conference presentations and, potentially, grant applications.
The postdoctoral position is full-time and fixed term – available for 12 months from January 2020 onwards – with strong prospects for a 2-year extension. Salary range is A$95,449-A$102,091 per year.
To apply, email a cover letter, CV and contact details of 3 referees to Prof Katharina Gaus (email@example.com) by 1st Nov 2019.
Scientia Professor Katharina Gaus MPhil PhD (Cantab)
NHMRC Senior Research Fellow
THE UNIVERSITY OF NEW SOUTH WALES | UNSW SYDNEY NSW 2052 AUSTRALIA
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