Project: The molecular basis of a novel host cellular defense pathway against infection
A postdoctoral fellowship is available in the Sixt lab at Umeå University (Sweden). The Sixt lab applies state-of-the-art tools in molecular genetics, microscopy, and high-throughput genetic and small compound screening to study the molecular basis of cell-autonomous immunity and bacterial evasion mechanisms during infection with the obligate intracellular bacterial pathogen Chlamydia trachomatis. The postdoc project aims to dissect the molecular composition of a recently identified novel pathway of programmed cell death induced during infection with Chlamydia trachomatis. Methodologies employed will include classic cell biological, biochemical, molecular genetic, and microscopic techniques, in combination with a CRISPR/Cas9 screening approach.
The full-time scholarship is for 1+1 years (with possibility for further prolongation depending on satisfactory performance). Starting date: as soon as a suitable candidate can be found.
You must hold a University degree equivalent to a European University PhD in molecular biology, cell biology, or microbiology (or equivalent). Priority will be given to candidates who have completed their doctoral degree no more than three years before the closing date of the application. Thorough theoretical and practical knowledge in molecular and cell biology is a prerequisite. Knowledge within the field of infection biology and/or programmed cell death is considered an advantage. Bioinformatics skills, such as experience in handling and analyzing data from next-generation sequencing projects, are considered an advantage, but are not a pre-requisite, because bioinformatics support is available. The ideal candidate should be passionate about science and be willing to take on scientific and technical challenges. The candidate should be proficient in written and spoken English and is expected to work both independently and as part of an interactive team.
To apply for the fellowship, the applicant should prepare a single PDF (max 5 pages) containing: 1) a letter of motivation describing the applicant’s interest in the project and how the applicant’s previous experience and skills can contribute to the project, 2) a curriculum vitae including a description of the methods that the applicant has mastered, and 3) names and e-mail addresses for two or more references, with stated professional relationship to the applicant. Applications should be written in English.
The application PDF should be sent to email@example.com. Applications are possible from now until a suitable candidate was found. Applicants may address questions to Barbara Sixt: firstname.lastname@example.org.
The Sixt lab is part of the Laboratory for Molecular Infection Medicine Sweden (MIMS) at Umeå University. MIMS is part of the Umeå Centre for Microbial Research (UCMR) that includes researchers active in the fields of molecular and clinical microbiology, molecular biology, chemistry and physics and is also closely connected to the university hospital. MIMS also constitutes the Swedish node of the Nordic EMBL Partnership for Molecular Medicine that was established to facilitate scientific collaboration between the partner institutes and to facilitate access to scientific infrastructure. Overall, MIMS provides a stimulating, collaborative, and highly international research environment with excellent access to modern research facilities.
• Sixt Lab website: http://www.mims.umu.se/groups/barbara-sixt
• Laboratory for Molecular Infection Medicine Sweden (MIMS): http://www.mims.umu.se/
• Nordic EMBL Partnership for Molecular Medicine: https://projects.au.dk/nordic-embl-partnership/
• Umeå Centre for Microbial Research: http://www.ucmr.umu.se/