PURPOSE OF POSITION: Dr. Miethke’s Autoimmune Liver Disease Laboratory seeks a research fellow to perform and analyze single cell genomics studies on liver tissue samples from patients and from animal models of primary sclerosing cholangitis, autoimmune hepatitis, or biliary atresia. These studies will involve cutting-edge, high-dimensional, immune-system measurements (e.g., single-cell RNAsec, scATAC sec, and spatial transcriptomics) and will be analyzed in collaboration with Dr. Emily Miraldi providing expertise in computational and systems biology. Studies will be performed in partnership with other investigators of the Division of Pediatric Gastroenterology focusing on single cell genomics and organoid studies to unravel disease mechanisms of inflammatory liver and gut diseases (including inflammatory bowel disease) to develop novel and targeted therapies. The mathematical modeling frameworks utilized between the Miethke and Miraldi labs span mechanistic (e.g., dynamic gene regulatory networks) to deep learning (e.g., prediction of cellular epigenomes from DNA sequence). Situated at Cincinnati Children’s Hospital, we are dedicated to studies that will ultimately improve the health of children. The ideal candidate will collaborate closely with other computational biologists in the Divisions of Immunobiology and Bioinformatics, with physicians, and with clinical research coordinators of the Center for Autoimmune Liver Disease (CALD). The Miethke investigative team is dedicated to compassionate translational research for and with patients with autoimmune liver disease and their family members.
-Ph.D. in related discipline, MD, or equivalent degree
The ideal candidate will have a quantitative background in computational/systems biology, engineering, computer science, statistics, math, or a related field, and some experience in wet bench biomedical research. He or she will also (1) be a fluent programmer in at least one language (e.g., Python, R, MATLAB) and be willing to develop fluency in other languages, as needed, (2) have research experience in machine learning, bioinformatics and/or mathematical modeling, and (3) a trackable publication record. An enthusiasm and willingness to develop immunology expertise on the job is also necessary.
Cincinnati Children’s Hospital Medical Center is a premier pediatric research institution with over 900 diverse and productive faculty members. Here, researchers work collaboratively across specialties and divisions to address some of the biggest challenges we face today in improving child health. A strong network of research support services and facilities, along with institutional commitment to research, push our team of faculty, postdocs and support staff to explore the boundaries of what is possible, leading to significant breakthroughs. We are driven by our mission to improve child health and transform the delivery of care through fully integrated, globally recognized research, education and innovation.
Post-doctoral research fellows at Cincinnati Children’s are valued for their unique interests and strengths, and are supported by our institution’s strong programming for post-docs through the Office of Postdoctoral Affairs and the Office of Academic Affairs and Career Development. Mentoring, support for international students and an emphasis on crafting high-quality grant proposals are only a few of the features that set our program apart. Cincinnati Children’s is a respected part of the broader, and very vibrant, Cincinnati community. With a thriving arts scene, numerous festivals celebrating music and food, a passionate fan following for our college and professional sports teams, and a variety of opportunities for outdoor activities, our region is truly a great place to work and live.