University of Pennsylvania (PENN)

Postdoctoral Research Fellow Positions in RNA Biochemistry at the University of Pennsylvania

University of Pennsylvania, Perelman School of Medicine

Philadelphia, PA, United States

Multiple postdoctoral research fellow positions are available for highly motivated, self-directed researchers who are interested in RNA biochemistry and Epigenetics to join a well-funded research laboratory focused on Epitranscriptomics in the Department of Biochemistry and Biophysics at University of Pennsylvania (Penn).

The ideal candidates with a strong background in biochemistry, bioinformatics, and molecular biology are encouraged to apply. Lab experience on one or more of the following protein purification, mass spectrometry, RNA biochemistry, structural biology, Cryo-EM and deep sequencing technologies are highly desirable.

As a private Ivy League research university, Penn offers a world-class environment for research in RNA biology and gene transcription regulation. The successful candidates will have access to the state-of-the-art equipment and study the regulation of energy homeostasis in mammals and RNA signaling in an interdisciplinary collaborative research group. Philadelphia is the sixth-most populous city in the United States, notable for its rich history and fun to live. A broad range of career-advancement and specialized training opportunities is available on campus throughout the year. Numerous recreational activities are routinely organized at Penn.

• Competitive starting salary, depending on previous experience and qualifications. The wage for fresh Ph.D. graduate without postdoctoral experience starts at $49,000 per year plus eligible benefit based on Penn’s postdoctoral policy and increases every year.
• The appointment will be renewable on a yearly basis, for a maximum of 5 years.

• Ph.D. in Chemistry or Biology
• Substantial knowledge and lab experience with at least one of the following areas protein expression and purification, cellular experiments in the mammalian system, DNA/RNA biology, and advanced mass spectrometry technologies (Triple Quadrupole Mass Spec, Q-TOF, Orbitrap, TOF/TOF), or X-ray macromolecular crystallography.
• Experience in data analysis and report preparation.
• Experience in preparing lab reports and manuscripts. Ability to effectively interact with research and technical staff in a team-oriented manner, Capability to develop experimental strategies.
Highly motivated, result-focused, autonomous, and organized person.

DUTIES and RESPONSIBILITIES (some of the following are mandatory)
• Performing RNA extraction and RNA library preparation (RNA-seq, CLIP-seq, MeRIP, ribosome profiling)
• Cloning, expression, and protein purification
• Familiar with a basic level of Linux language and performing high-throughput sequencing data analyses
• Conducting biochemistry experiments, including protein activity assays, protein-RNA binding affinity determination, and kinetics
• Responsible for keeping detailed records of procedures and experiments in the laboratory notebook. Compiling data, making necessary calculations, presenting results at national and international conferences, and publishing the results in high-impact journals.
• Instructing and training students, technicians, and laboratory assistants as required.
• Understanding and adhering to Penn’s compliance standards as they presently exist and as they change or are modified.
• Performing other job-related duties as required or specifically assigned by the Principal Investigator.

The RNA biology and Epigenetics laboratory is led by Dr. Kathy Fange Liu, Assistant Professor of Biochemistry and Biophysics. This laboratory is funded by both Penn and a substantial NIH research grant (lab web site: and Please direct inquiries, CV, and contact information of three references via email to the Principal Investigator at


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Postdoctoral Research Fellow Positions in RNA Biochemistry at the University of Pennsylvania