Merck Sharp and Dohme Limited (MSD UK)

Postdoctoral Research Fellow – Mitochondrial-Lysosomal contact sites as a means of recovering mitochondrial function)


London, United Kingdom

Our presence in the UK goes back a long way. For over 80 years, we’ve been researching, developing and supplying new medicines and vaccines that prevent and treat diseases that occur at every stage of life. Today we’re one of the top five biopharmaceutical companies in the UK and employ over 2,000 people across five sites in Hertfordshire, Northumberland, Buckinghamshire, Edinburgh and London. We are officially certified by the Top Employer Institute and been awarded the exclusive Top Employer United Kingdom Certification for the second year running.

We are establishing a new state-of-the-art life early science & innovation sciences research facility in London. With a mission of turning breakthrough science into meaningful and impactful medicines, the research focus is cellular ageing and mechanisms of homeostasis and resilience, the basis of some of the most challenging diseases facing our ageing population.

Our opportunity to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

We are currently recruiting Postdoctoral Research Fellow – (Mitochondrial-Lysosomal contact sites as a means of recovering mitochondrial function)

Be a part of the legacy: Postdoctoral Research Fellow Program

Position Overview:

Our London Discovery Centre is seeking a passionate and driven postdoctoral researcher with expertise in microscopy, molecular biology and cell biology to join our Mitochondrial Dysfunction Team for a 3-year position. The focus of the group is understanding key determinants of mitochondrial dysfunction which can be effectively targeted with novel medicines for age-related conditions, with a primary interest in neurodegeneration.

The overarching aim of this project is to gain mechanistic insight into the role of mitochondrial-lysosomal contact sites in recovering mitochondrial function and cellular homeostasis via repair rather than degradative mitophagy. This ‘repair’ pathway may be important in understanding dysfunctional mitochondrial pathology in Parkinson’s disease and Alzheimer’s disease, within which the mitochondrial degradation pathway (mitophagy) is compromised.

The postdoctoral fellow will benefit from access to state-of-the-art equipment, including high-content imaging and super-resolution fluorescence microscopy. They will be supported by senior scientists with extensive experience in mitochondrial biology, molecular biology, cell biology (including iPSCs) and neuroscience, and be expected to interact with the wider mitochondrial biology network and academic collaborators.

Responsibilities include but are not limited to:

  • Delivering high quality, reproducible experimental data, which is hypothesis driven (key responsibility)
  • Being up-to-date on literature in the field
  • Manuscript preparation 
  • Contribute to laboratory running and be a conscientious member of the team
  • Timely write-up of reports and data
  • Regular presentations at internal meetings and at external meetings if the opportunity arises.

Education Minimum Requirement:  

  • Candidates must currently hold a PhD OR receive a PhD by fall

Required Experience and Skills:

  • Mammalian cell culture experience
  • Confocal microscopy / fluorescence microscopy, Image analysis of fluorescence images
    • Molecular Biology – DNA/RNA isolation, Western blotting, transfection
    • Excellent written and oral communication skills
    • Understanding of statistics

    Preferred Experience and Skills: (List 3 to 5 Preferred Skills)

    • Understanding of mitochondrial biology
    • Preparation of primary cell culture and differentiation of iPSC cell culture
    • Gene editing – CRISPR

    We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

    Who we are …

    Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

    We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

    What we look for …

    In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.




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