The Masonic Medical Research Institute (mmri.edu) is looking for enthusiastic candidates to join the laboratory of Dr. Nathan Tucker (www.mmri.edu/tucker-lab/ ). Successful candidates will join a research program which focuses on mechanistically understanding the effects of human variation (such as that identified by GWAS) on cardiovascular phenotypes.
Specific projects include defining epigenomic changes in normal and disease conditions, single-cell RNA sequencing for discovery and definition of novel cell states in human disease, large-scale CRISPR-mediated screening of coding and non-coding variant function, assessment of disease-causing variation in model organisms, and intersection of all previously mentioned data with human population genetics and health outcome data.
Our group has extensive national and international collaborations, including groups at the Broad Institute of MIT and Harvard, Massachusetts General Hospital, and the University of Pennsylvania.
For recently published work, please see: https://www.ncbi.nlm.nih.gov/myncbi/nathan.tucker.1/bibliography/public/
and see our recent preprints on chromatin conformation and single cell RNA sequencing at:
- An advisor who will be regularly involved in honing the direction and progress of your research; active management will be tailored to the candidate’s needs and desires.
- An opportunity to present your work at national/international conferences.
- Support for publication of high and medium impact journal articles. We are also strong advocates of preprints.
- A supportive environment that keeps your short and long-term career goals in mind. Your success is our success!
- Clear expectations provided in structured project management.
- A closely-knit, exceptionally equipped research institute with a wide variety of research interests and expertise.
- An appreciation for work/life balance; sometimes the best ideas come when not in the lab!
- A highly competitive compensation and benefits packages.
- A position in the very affordable Mohawk Valley of Upstate New York: an ideal region for those interested in myriad outdoor adventures including those in the Adirondack State Park, the largest park in the contiguous United States.
Required Skills and Attributes:
- A recent or pending PhD in the biological sciences or related fields.
- A research background in cell and molecular biology and experience with standard workflows within these fields. Experience in microscopy and next generation sequencing, including analyses of these data are highly desirable.
- Experience with model organism and/or cell culture work. Experience with iPSCs is highly beneficial.
- Demonstrated productivity in the form of first author publications and presentations.
- Excitement to tackle difficult scientific questions in areas that will involve significant development of technical and analytical workflows.
- Scientific creativity to identify novel approaches to answer our research questions.
- A hard working and collegial attitude.
- A desire to work in an informal, highly collaborative, and scientifically rigorous laboratory environment.
- Computational experience (command line, R, Python, Fiji, MATLAB) is a plus.