Massachusetts Eye and Ear Infirmary (MEEI)

Postdoctoral Research Fellow in Single Cell Genomics and Complex Disease Genetics

Massachusetts Eye and Ear, Harvard Medical School

Boston, MA, United States

POSITION SUMMARY:

The laboratory of Dr. Ayellet Segre at the Ocular Genomic Institute at Massachusetts Eye and Ear (MEE) and Harvard Medical School, that is affiliated with the Broad Institute of Harvard and MIT, is seeking a talented and highly motivated Postdoctoral Fellow interested in developing and applying computational methods for single cell genomics in eye tissues and large-scale human genetic association studies to investigate the genetic and biological causes of complex eye diseases. MEE is a teaching hospital of Harvard Medical School and is an international leader for treatment and research in both Ophthalmology and Otolaryngology. The Segre lab develops statistical and computational methods that integrate human genetics, functional genomics, and systems biology approaches to identify new causal genes and regulatory mechanisms that lead to common eye diseases, including glaucoma, age-related macular degeneration, and diabetic retinopathy, with the ultimate goal of proposing new therapies for eye disease. To learn more about the lab please visit: https://segrelab.meei.harvard.edu/.


The successful candidate will have a strong background in (bio)statistics, statistical genetics, mathematics, computational genomics, bioinformatics, or a related quantitative field, strong programming skills, and be excited to contribute to advancing science and medicine of complex eye diseases. Research projects will involve developing statistical and computational methods for the analysis of single cell RNA-seq of human eye tissues and whole genome sequencing to identify cell type-specific genetic regulation, and integrating the results with genome-wide association studies (GWAS) to uncover novel pathogenic processes and cell types for common eye diseases. The project will be part of an exciting multi-lab collaboration aimed at generating a Human Cell Atlas of the healthy eye from childhood to old age: https://chanzuckerberg.com/science/programs-resources/humancellatlas/seednetworks/cell-atlas-of-the-human-eye-from-birth-to-old-age/. The postdoctoral fellow will have the opportunity to develop his or her own research projects and interests within this research area, and to present ones work at local, national, and international meetings.

 

REQUIRED EDUCATION AND EXPERIENCE:

  • Ph.D. in (bio)statistics, statistical genetics, human genetics, computational genomics, bioinformatics, mathematics, computer science, or a related quantitative discipline required.
  • Strong programming skills and in-depth experience with several programming languages required, e.g., Python, R, Matlab, C++.
  • Experience with Unix/Linux environments required, including shell scripting.
  • Experience with large-scale biological data analysis, algorithm development, and statistics required; work with next-generation sequencing, single cell RNA-sequencing, GWAS, or other -omics data preferred.
  • Research experience and knowledge in statistical genetics, regression models, and/or machine learning desired.
  • Demonstrate independent critical thinking and rigorous work.
  • Strong record of productivity and good publication record in peer-reviewed journals.
  • Strong personal skills, and excellent verbal and written communication skills.
  • Ability to work effectively both independently and collaboratively in a fast-paced, academic environment and evolving field. 
  • Prior knowledge of ocular diseases not required.

 

WORK ENVIRONMENT:

The Segre lab is located in the main hospital building of Mass Eye and Ear (MEE) in a research and office work space that is part of the Ocular Genomics Institute at MEE. The candidate will work among a vibrant team of computational biologists, computer scientists, and statistical geneticists and will be part of a larger multidisciplinary research environment at the Ocular Genomics Institute, which includes geneticists, clinical scientists, and experimental biologists. The candidate will have the opportunity to interact with colleagues at other universities in the fields of human genetics, single cell genomics, and functional genomics, and with the Medical and Population Genetics community at the Broad Institute of Harvard and MIT.


To apply, please send your CV, a cover letter describing previous research experience and research interests, and contact information for 3 references to:


Dr. Ayellet Segre

Ocular Genomics Institute

Mass Eye and Ear

243 Charles St

Boston, MA 02114

Ayellet_Segre@meei.harvard.edu


Massachusetts Eye and Ear is an affirmative action/equal opportunity employer.

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Postdoctoral Research Fellow in Single Cell Genomics and Complex Disease Genetics