Fred Hutchinson Cancer Research Center

Post-Doctoral Research Fellow, Human Immunology

Fred Hutchinson Cancer Research Center

Seattle, WA, United States

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Newell Lab (publication list)was originally established in 2012 at the Singapore Immunology Network, Singapore and then moved to the Vaccine and Infectious Disease Division of the Fred Hutchinson Cancer Research Center in August 2018.

A major goal of lab is to exploit T cell antigen-specificity to gain clinically relevant insights about human immunity in the context of cancer and infectious disease. This is achieved through leveraging expertise in the use of highly-multiplexed peptide-MHC tetramer staining in conjunction with mass cytometry or single-cell sequencing to deeply profile human antigen-specific T cells. In addition, novel experimental and computational approaches are being developed that allow for improved examination of T cell phenotypes, function, antigen specificity, as well as T cell receptor repertoire. Although the lab focuses mostly on studying the roles of T cells in human health and disease, we also participate in many projects related to other cell types and mouse tumor systems are also employed.

Our Lab is seeking outstanding and open-minded Postdoctoral Fellows to work on developing and implementing cutting edge analysis to investigate the roles of T cells in various models of cancer and infectious disease.

Responsibilities

  • Learning nuances of implementation of mass cytometry and single-cell sequencing based approaches for the analysis of relevant cellular samples
  • Application of highly multiplexed peptide-MHC multimer analysis using mass cytometry
  • Experimental design, planning and coordination with collaborators
  • Initiate and carry out scientific projects, under the supervision of Evan Newell
  • Develop new ideas for projects or approaches based on immunological interest and knowledge of the literature
  • Conduct and publish research in appropriate journals.

Qualifications

  • A doctoral degree in immunology, biochemistry, life sciences or related fields
  • Experience with flow cytometry and/or single cell sequencing required (mass cytometry experience preferred but not required)
  • An interest in T cell immunology
  • Computer programming or bioinformatics skills would be very advantageous but not required
  • Experience with protein expression and purification would also be advantageous
  • An ability to learn new techniques and troubleshoot assays
  • Good team player, independent, self-driven with good interpersonal skills

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

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Quote Reference: 13908

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