Fred Hutchinson Cancer Research Center

Post-Doctoral Research Fellow, DNA Break Repair and Recombination

Fred Hutchinson Cancer Research Center

Seattle, WA, United States

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A post-doctoral research fellow is available in the Smith Laboratory, that studies the molecular basis of recombination using both S. pombe and E. coli as model organisms. The responsibilities of this position will be to to study S. pombe meiotic recombination or E. coli recombination and DNA break repair by RecBCD enzyme

In S. pombe we use a variety of techniques – genetic, biochemical, and microscopic – to discover the molecular mechanism of meiotic recombination and how it is controlled to occur at the right time and place along chromosomes. Current studies include elucidating the mechanism of crossover interference, which involves DSB hotspot clustering by linear element proteins, DSB interference, and DSB competition. See Fowler, Hyppa, Cromie, and Smith, PNAS 115: E9333 – E9342 (2018), PMID: 30217891.

In E. coli, we use genetics, enzymology, and electron microscopy to study how RecBCD helicase-nuclease is controlled by Chi recombination hotspots. Current studies include testing our nuclease-swing model for Chi’s control of the nuclease during DNA unwinding. See Amundsen and Smith, NAR 47: 197 – 209 (2019), PMID: 30445486.

Qualifications

A Ph.D. in biology or related fields and experience in genetics or biochemistry is required. Experience with microbes is valuable but not essential. Compensation will follow the NIH guidelines for postdoctoral fellows. Start date is flexible.

Our Commitment to Diversity

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

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Quote Reference: 14977