Post-Doctoral Research Associates in Telomere Biology and Genome Stability
Applications are invited for two Post-Doctoral Research Associate positions in the laboratory of Dr. Svetlana Makovets at the Institute of Cell Biology, University of Edinburgh. The Makovets lab is interested in molecular mechanisms governing genome stability, and in particular DNA repair and telomere biology.
Position 1 (Ref 047944) – Cellular responses to telomerase insufficiency.
We have previously developed a yeast-based system to analyse cellular responses to telomerase insufficiency (Millet et al., 2015 and unpublished data), a condition highly relevant to carcinogenesis and ageing in humans. The successful applicant will continue exploring the yeast model as well as establish and investigate a similar system in human cells in order to understand telomere metabolism and population dynamics during telomerase insufficiency.
Position 2 (Ref 047945) – Telomere maintenance in cells with DNA damage.
We have previously described how telomere maintenance and DNA repair are modulated through the post-translational modifications of the Pif1 helicase (Makovets and Blackburn, 2009; Vasianovich et al., 2014). The successful applicant will further investigate how telomerase is co-ordinated with DNA replication and repair machineries in the budding yeast model system, with a possibility to transition to a mammalian model.
Applicants should be enthusiastic and highly motivated, with good analytical thinking, experience in molecular biology, and a proven track record in producing high quality data suitable for publication.
Applicants must have, or shortly obtain, a PhD in a relevant field.
The position is for a fixed term of 1 year in the first instance, with the possibility of extension. The start date is flexible.
Informal enquiries may be made to Sveta.Makovets@ed.ac.uk
Applications should be made via the University of Edinburgh Jobsite: https://www.vacancies.ed.ac.uk