Salary Range: $47,000-50,000, Full Time, Department of Ophthalmology
Estimated Duration of Appointment: 1-3 y
Position Summary: We are seeking a talented postdoctoral fellow to join our team to study the use of full-length intact genes from genomic loci for gene therapy applications. Research project involves the development of gene therapy strategies using part or whole genomic loci and study their transgene expressions in retinitis pigmentosa (RP) mouse models. The overall goal of the project is to study the mechanistic functions of genomic DNA transgene, in which the native promoter, enhancer, and other critical non-coding elements drive and control expression, compared to the conventional cDNA/minigene-based vectors for gene therapy of RP (https://www.med.unc.edu/ophth/directory/zongchao-han-ph-d-m-d/). The project is supported by NIH.
Educational Requirements: Candidates must have a PhD in the field of molecular genetics, cellular biology and biochemistry. They need to have a solid experimental background including studies with DNA, RNA and/or protein, imaging/fluorescence microscopy, cell culture, NGS, single-cell transcriptomics as well as hands-on experience with laboratory animals. Candidates should have strong communication skills (both orally and in writing), a critical scientific attitude, a high level of ambition, excellent problem solving skills, and should be able to work both independently as well as in a team.This position offers an excellent opportunity to learn and apply skills in genetics, molecular biology, gene augmentation therapies, and evaluation of animal models of disease. Experience in one or more of these areas is preferred. Experience in retinal gene therapy is a big plus. Candidates should have at least 1-2 English language authored papers.