King's College London (KCL)

Postdoctoral Research Associate

King's College London (KCL)

London, United Kingdom

Postdoctoral Research Associate – Gene Therapy and Nanomedicine

Centre for Craniofacial and Regenerative Biology
Ref. 024286
The salary will be paid at Grade 6, £38,304 per annum, inclusive of London Allowance.
This post will be offered on a fixed-term contract for 2 years.
This is a full-time post.

We are seeking a highly motivated and talented postdoctoral researcher for a 2 year fixed-term contract, starting March 1st, 2019, to develop nanomaterial-based gene delivery strategies for the topical treatment of genetic skin conditions. We are looking for someone with a strong experience with cloning and in vitro RNA transcription. Further, experience with in vitro and in vivo transfection optimization in hard-to-transfect cells is required. Experience with nanomaterials for drug delivery, optical microscopy and cell biology would be advantageous.

The typical candidate will have:

  • PhD in Biology, Bioengineering, Biochemistry or related field.
  • Cloning experience.
  • In vitro RNA transcription experience.
  • Gene therapy experience.
  • Evidence of productivity through high quality publications.
  • Strong work ethics.
  • Independence and team-work ability.

The Nanomaterials and Biointerfaces group of Dr. Chiappini is based in the Centre for Craniofacial and Regenerative Biology at King’s College London. The group blends nanotechnology, bioengineering and cell biology to develop advanced materials for dynamic with intracellular interaction. We leverage this controlled cell interaction to engineer platforms for regenerative medicine and precision medicine. This project is in collaboration with the groups of Professor John McGrath and Professor Jakub Tolar at the University of Minnesota. For more information visit http://chiappinilab.com

This exciting project is to investigate nanomaterial-based strategies for the local targeted delivery of nucleic acids to exposed skin wounds due to genetic skin disease. The aims of the project are to identify an efficient delivery strategy to skin organoid cultures and in a murine animal model (collaboration UNM), and validate the correction of the genetic defect, alongside its effects promoting wound healing. The work follows up from two of our recent publications on nanodelivery strategies for DNA plasmids (Chiappini et al. Nature Materials 2015) and gene-therapy correction of skin diseases (Georgiadis et al. Journal of Investigative Dermatology 2016).

The selection process will include a panel interview, an assessment, a presentation.

Informal inquiries are strongly encouraged. ciro.chiappini@kcl.ac.uk

To apply, please visit https://bit.ly/2XYNDIg and register with the King’s College London application portal and complete your application online.

Closing date: 07/01/2020

Please apply via recruiter’s website.

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