Postdoctoral Research Associate in Synthetic Biology, Protein Architectures and Superselectivity
We are seeking to appoint a Postdoctoral Research Associate to join Prof Mark Howarth’s lab to generate new kinds of protein teams. SpyTag is a genetically-encoded peptide forming an irreversible covalent bond to its protein partner SpyCatcher. SpyTag has been applied around the world, including towards enhanced vaccines (for infectious diseases and personalized medicine) and arming antibodies or T cells for cancer immunotherapy. This project will harness the structural diversity in the Protein Data Bank to generate a diverse toolbox of protein teams, as an important resource to address questions in immunology, cell signalling and enzyme biotechnology. In particular, through collaboration with Ralf Richter at the University of Leeds, the project will study the phenomenon of superselectivity, to develop nanostructures with switch-like dependence on cellular expression levels, towards enhanced therapeutic targeting. The Howarth group currently works on areas including vaccines for global health, force-dependent cell signalling, and therapeutic targeting in the blood and GI tract. We will provide training in unfamiliar methods.
You should hold a PhD/DPhil, or be near completion of a PhD/DPhil in Biochemistry, Cell Biology or a related area. You will have experience in molecular biology approaches, recombinant protein expression and cellular analysis, with excellent communication skills and the ability to write for publication and present research proposals and results. Skills in structure-based engineering of proteins or microscopy are advantageous but not essential.
This full-time fixed-term post is funded by EPSRC for up to 2 years in the first instance and is based at the Department of Biochemistry, South Parks Road, Oxford.
This position is graded on the University’s Grade 7 pay scale, for which the salary range is £32,817 – £40,322 per annum, however the actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. This is unlikely to be more than £34,804 per annum.
For further general information, phone (01865) 613204, quoting reference number 146555.
Applications for this vacancy are to be made online.
To apply for this role and for further details, including the job description and selection criteria, please click on the link below:
The closing date for applications is 12.00 noon on Monday 27th July 2020, with interviews for shortlisted candidates to be held as soon as possible thereafter.