University of Oxford

Postdoctoral Research Associate in Synthetic biology and SpySwitches

University of Oxford

Oxford, United Kingdom

Postdoctoral Research Associate in Synthetic biology and SpySwitches

We are seeking to appoint a Postdoctoral Research Associate to join the group of Prof Mark Howarth to advance a new generation of protein interactions. SpyTag is a genetically-encoded peptide forming an irreversible covalent bond to its protein partner SpyCatcher. SpyTag has been applied around the world, including for vaccines (for infectious diseases and personalized medicine) and arming antibodies for cancer immunotherapy. Cyclization using SpyTag/SpyCatcher allows major increases in resilience of enzymes, as needed in nutrition and green chemical transformation. This project will apply novel library-based selections and rational design to create new SpySwitch technologies, enabling switchable reaction in response to light and other cellular conditions. There will then be the opportunity to apply these new generation pairs towards one project of special interest to the appointee. The Howarth group are currently working on areas including vaccines for global health, immuno-oncology, force-dependent cell signalling (mechanobiology), and therapeutic targeting in the blood and GI tract. We will provide training in unfamiliar methods.

You should hold a PhD/PDPhil, or be near completion of a PhD/DPhil in Biochemistry, Cell Biology or a related area. You will have experience in molecular biology approaches and recombinant protein expression and have excellent communication skills, with the ability to write for publication and present research proposals and results. Skills in library-based selection, structure-based engineering of proteins, or fluorescence microscopy are advantageous but not essential.

This full-time fixed term post is funded by BBSRC for up to 3 years in the first instance and is based at the Department of Biochemistry, South Parks Road, Oxford.

This position is graded on the University’s Grade 7 scale, for which the salary range is £32,817 – £40,322 per annum. The actual starting salary will be based on qualifications and relevant skills acquired and will also be determined by the funding available.

For further general information, phone (01865) 613204, quoting reference number 144329.

Applications for this vacancy are to be made online.

To apply for this role and for further details, including the job description and selection criteria, please click on the link below:

The closing date for applications is 12.00 noon on Monday 6th January 2019, with interviews for shortlisted candidates to be held as soon as possible thereafter.

The University of Oxford is a member of the Athena SWAN Charter and holds an institutional Bronze Athena SWAN award. The Department of Biochemistry is strongly committed to equality and valuing diversity and we operate a flexible working policy for all staff. The Department holds a departmental Silver Athena award in recognition of its efforts to introduce organisational and cultural practices that promote gender equality and create a better working environment for both men and women.

Committed to equality and valuing diversity.

Please apply via recruiter’s website.