King's College London (KCL)

Post-doctoral Research Associate in epitope discovery

King's College London (KCL)

London, United Kingdom

Post-doctoral Research Associate in epitope discovery

Immunobiology
Ref: 030952
Grade 6, £38,304 to £41,517 per annum inclusive of £3,500 per annum London Allowance
This post will be offered on Fixed-term contract for 12 months
This is a full-time post – 100% full time equivalent

This post is made available through a Cancer Research UK – Programme Foundation Award. Dr Michele Mishto (Dep. of Immunobiology & CIBCI) is lead investigator of a project entitled “Identification of tumour-specific spliced epitopes to target large cohorts of cancer patients by immunotherapy”. The project is funded by Cancer Research UK (programme Foundation Award) for 6 years, beginning in 2021.

The successful candidate will be expected to lead, under the supervision of Dr Mishto, a programme of research whose principal aims are:

(i) to isolate CD8+ T cell clones specific for HLA-I-restricted spliced neoepitopes carrying recurrent driver mutations in in melanoma and pancreatic adenocarcinoma;

(ii) isolate and clone their TCRs and use them to investigate the epitope generation in cancer cells;

(iii) use TCRs to test their efficacy in treating cancer in xenograft mouse models.

Detailed knowledge of applied cellular and molecular biology and immunobiology, biochemistry cloning and mouse model would be highly advantageous.

The successful candidate will have opportunities to interact with national and international collaborators with a broad expertise, which varies from computational biology to clinics. This post will be located in the Centre for Inflammation Biology and Cancer Immunology (CIBCI) in New Hunt’s House on the Guy’s Campus, King’s College London.

The selection process will include a panel interview, an assessment, a presentation.

For an informal discussion to find out more about the role please contact Dr. Michele Mishto, michele.mishto@kcl.ac.uk

Closing date: Midnight on 22 July 2020

To apply, please visit https://bit.ly/31fmlAX and register with the King’s College London application portal and complete your application online.

Please apply via recruiter’s website.