Queen Mary University of London

Postdoctoral Research Assistant

Queen Mary University of London

London, United Kingdom

Postdoctoral Research Assistant

Salary: £33,615 per annum

Ref: QMUL18637

Applications are invited to work with Dr Pradeepa Madapura as a Postdoctoral Research Assistant in the Blizard Institute, Queen Mary University of London. The Blizard Institute is the largest institute of Barts and the London School of Medicine and Dentistry and aims to deliver excellence in all aspects of research, teaching and clinical service.

Dr Madapura’s group investigates the role of transcriptional enhancers in tissue-specific gene expression, with a focus on the human neuronal differentiation system and its alterations in neurodevelopmental disorders. We use cutting-edge functional genomics approaches to investigate how distal enhancers regulate genes and role of specific histone acetylations on enhancer function, with the aim of deciphering specific role of each histone acetylation complexes in tissue specific enhancer activity. The post-holder will play a key role in obtaining these datasets and investigating key candidate elements in human pluripotent stem cells and neuronal differentiation models. The data generated will provide the basis for follow-up functional studies, including using genome and epigenome editing methods to investigate the specific function of histone acetyl transferases and candidate enhancer elements.

References:

De Vas M et al https://www.biorxiv.org/content/10.1101/621029v1 

Olley, G. et. al. (2019) https://www.biorxiv.org/content/10.1101/632992v1

Olley, G. et al. Nat. Genet. 50, 329–332 (2018)

Pradeepa, M. M. et al. PLOS Genet. 13, e1006677 (2017)

Pradeepa, M. M. et al. Nat. Genet. 48, 681–686 (2016)

Taylor, G. et al. Genome Res. 23, 2053–2065 (2013)

Further information on the laboratory https://www.pradeepmadapura.com/ and the Institute can be found at: https://tinyurl.com/y9b3zll8. Madapura lab is a part of the QMUL epigenetics hub http://qmul-epigenetics-hub.co.uk/home. Different research groups with the epigenetics hub closely interact and collaborate to investigate epigenetic mechanisms in basic biological processes and disease pathogenesis.

The post is full time, fixed term appointment for 26 months, with an expected start date of 1st September 2019. Starting salary will be £33,615 per annum, inclusive of London Allowance. Benefits include 30 days annual leave, pension scheme and interest-free season ticket loan.

Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

Informal enquiries should be addressed to Dr Pradeepa Madapura at p.madapura@qmul.ac.uk or on +44 (0) 020 7882 2594.

Details about the institute can be found at www.blizard.qmul.ac.uk

To apply for the role, please click the ‘apply’ button below.

The closing date for applications is 15 June 2019. Interviews are expected to be held shortly thereafter.

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