The Laboratory for GPCR Biology located at the Department of Pharmacology & Chemical Biology (www.pharmacology.us) and funded by the NIH is seeking candidates for post-doctoral fellowship positions up to five years to determine signaling mechanisms underlying the function of PTH-receptor and other GPCRs such as the Ca2+-sensing and GABAB1 receptors at the molecular/structural/cellular levels using TIRF/FRET/confocal/epifluorescence microscopy and cryo-EM. The information obtained through this research will advance the development of new therapeutics for bone and mineral diseases, including medications for osteoporosis, hyperparathyroidism, and kidney diseases.
The conditions are a minimum two-year commitment, high-motivation, and interest in joining an interdisciplinary research team. We have weekly group lab meetings and a focused journal club. These activities provide a strong training environment. Salary and benefits are highly competitive with excellent career development opportunities.
Preference will be given to PhD or MD/PhD applicants with a solid experience in Biochemistry, Structural Biology or Cell Biology, and with at least 2 first-authored articles published in international journals. The University of Pittsburgh is an Equal Opportunity/Affirmative Action Employers with strong institutional commitments to diversity. Women and minority candidates are particularly encouraged to apply.
The University of Pittsburgh School of Medicine currently ranks 5th among NIH-funded academic medical centers, and the department is consistently one of the top NIH-funded departments of Pharmacology. The School of Medicine and the department are executing an exciting vision for both the expansion and integration of basic research, clinical investigation, and patient care missions. The department houses state-of-the-art facilities supporting microscopy, mass spectrometry, protein chemistry, gene expression profiling, genetic models of disease, receptor analysis, physiologic monitoring, physical chemistry, organic/combinatorial chemistry, cryo-EM, and high throughput drug discovery.
Send CV and letter of motivation to J-P. Vilardaga (firstname.lastname@example.org)
Selected recent publications:
b2-adrenergic receptor control of endosomal PTH receptor signaling by Gbg. Nature Chem. Biol. (2017, 10.1038/nchembio.2267)
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release. PNAS (2017, 10.1073/pnas.1800449115)
Ca2+ allostery in PTH-receptor signaling. PNAS (2019, 10.1073/pnas.1814670116)
Parathyroid Hormone Receptor: Structure, Allostery, and Signaling. Trends in Endocrinol & Metab. (2019, 10.1016/j.tem.2019.07.011)
Structure and dynamics of parathyroid hormone type 1 receptor in its long-active signaling state. Science (2019,10.1126/science.aav7942)
PTH Hypersecretion Triggered by a GABAB1 and Ca2+-sensing Receptor Heterocomplex in Hyperparathyroidism. Nature Metabolism (2020, in press)
Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR. PNAS (2020, in press)