Sloan Kettering Institute (SKI), MSKCC

Post-Doctoral Positions – Single-molecule Studies of Transcription, Chromatin, Gene Regulation and Genome Organization

Sloan Kettering Institute at MSKCC

New York, NY, United States

The Pertsinidis lab in the Structural Biology Program of the Sloan Kettering Institute at MSKCC has immediate openings for postdoctoral associates.

The lab’s focus is aimed at gaining a detailed and mechanistic understanding of the fundamental processes that control gene expression in live cells. Our lab has achieved some of the highest resolution single-molecule studies of transcription, including the first super-resolution imaging of RNA Polymerase II and regulatory factors at single gene loci in live cells (e.g. Wang et al. Cell 2016; Li et al., Cell 2019). Successful applicants will fully utilize the superb single-molecule and super-resolution technological capabilities of the lab and apply the tools developed to outstanding questions in gene regulation. Particular emphasis is currently on molecular and biophysical mechanisms of mRNA transcription, chromatin/epigenetic regulation, promoter-enhancer communication and the interplay of genome and nuclear architecture with gene expression regulation.

Requirements: Applicants must possess a Ph.D. degree in Molecular and Cellular Biology, Biochemistry, Biophysics, Physics, Chemistry, or a relevant field. Demonstrated ability to work effectively in a collaborative, multidisciplinary environment is essential. Experience with single-molecule detection instrumentation and/or high/super-resolution optical imaging is preferred but not required. Individuals with additional working knowledge of stem cell biology, developmental biology and/or genetics/genome editing techniques are strongly encouraged to apply. Please apply by sending your CV, names and contact information of three references, and a short description of your scientific interests by email to Dr. Alexandros Pertsinidis (PertsinA(at)

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision. Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.

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Post-Doctoral Positions – Single-molecule Studies of Transcription, Chromatin, Gene Regulation and Genome Organization