The Pertsinidis lab in the Structural Biology Program of the Sloan Kettering Institute at MSKCC has immediate openings for postdoctoral associates.
The lab’s focus is aimed at gaining a detailed and mechanistic understanding of the fundamental processes that control gene expression in live cells. Our lab has achieved some of the highest resolution single-molecule studies of transcription, including the first super-resolution imaging of RNA Polymerase II and regulatory factors at single gene loci in live cells (e.g. Wang et al. Cell 2016; Li et al., Cell 2019). Successful applicants will fully utilize the superb single-molecule and super-resolution technological capabilities of the lab and apply the tools developed to outstanding questions in gene regulation. Particular emphasis is currently on molecular and biophysical mechanisms of mRNA transcription, chromatin/epigenetic regulation, promoter-enhancer communication and the interplay of genome and nuclear architecture with gene expression regulation.
Requirements: Applicants must possess a Ph.D. degree in Molecular and Cellular Biology, Biochemistry, Biophysics, Physics, Chemistry, or a relevant field. Demonstrated ability to work effectively in a collaborative, multidisciplinary environment is essential. Experience with single-molecule detection instrumentation and/or high/super-resolution optical imaging is preferred but not required. Individuals with additional working knowledge of stem cell biology, developmental biology and/or genetics/genome editing techniques are strongly encouraged to apply. Please send a CV, names and contact information of three references, and a short description of your scientific interests by email to Dr. Alexandros Pertsinidis (PertsinA@mskcc.org).
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