Case Western Reserve University (CWRU)

Post-doctoral positions in multi-‘omic studies of the microbiome in HIV & Cancer

Case Western Reserve University (CWRU)

Cleveland, OH, United States

Post-doctoral positions in multi-‘omic studies of the microbiome in HIV & Cancer

Dr. Adam Burgener invites applications for full time post-doctoral positions at the Center for Global Health and Diseases at Case Western Reserve University. Funding is available for multiple positions for 5 years. These positions are funded by multiple sources including two of Dr. Burgener’s recent Canadian Institutes for Health Research (CIHR) Team Grant awards: the first from the Canadian Microbiome Initiative and the second by the HIV/AIDS Biomedical and Clinical Research award programs. These are research grants utilizing multi-‘omic approaches to study the microbiome, proteome, metabolome, and inflammation in viral infection and disease pathogenesis.

Qualifications: We are looking for candidates in two general areas to support these research projects including:

Metagenomics: A Ph.D. degree in Microbiology, Immunology, Genetics, Biochemistry, or related discipline with expertise in the microbiome and disease. Experience in metagenomics, shotgun sequencing, 16S rRNA analysis, and/or rtPCR of the microbiome is a requirement, including data analytics of genomic datasets. Anaerobic bacterial culture is an asset. Knowledge of proteomics and/or other areas of systems biology would be an asset but not required.

Proteomics/Metabolomics: A Ph.D. degree in Chemistry, Biochemistry, Microbiology, Immunology, or related discipline with expertise in mass spectrometry and metabolomics. Experience in metabolomics, proteomics, and tandem mass spectrometry is a requirement, including data analytics of mass spectrometry data. Experience in studies of the microbiome in human disease would be an asset. Knowledge of other areas of systems biology would be an asset but not required.

Pay scale: This pay would be set at NIH rates and commensurate with experience. Those successful at acquiring external fellowships would be eligible for a merit increase.

Research lab: Dr. Burgener’s research group at the Center for Global Health and Diseases (CGHD) (https://case.edu/medicine/globalhealth/) is situated at the Biomedical Research building at the School of Medicine in Cleveland, Ohio. Our research lab specializes in using systems biology tools to study biological processes important for human health, including inflammation, host immunity, and the microbiome. We are a highly interdisciplinary team of scientists, post-doc’s, graduate students and technicians. Our lab has made discoveries important for reproductive health, including how the microbiome affects susceptibility to HIV and drugs for HIV prevention (DOI: 10.1126/science.aai9383). We have numerous international collaborations and partnerships and have funding from the National Institutes of Health and the Canadian Institutes of Health Research. This position will be located in our new state-of-the-art laboratory at Case Western Reserve University, which contains the latest equipment in molecular studies, including Thermo Fisher tandem mass spectrometers for proteomics, metabolomics, and targeted molecular analysis; Illumina sequencers, rtPCR; and tissue and anaerobic bacterial culture systems for in vitro assays. Our collective group has a wide diversity of experience in proteomics, systems biology, bioinformatics, immunology, mouse models, in vitro co-culture, and metagenomics for microbiome research. Case Western Reserve University houses core facilities for advanced genomic sequencing, animal model studies, immunology, microscopy, and a wide array of platforms for translational research.

Position description: We are looking for individuals who have an interest in studying the microbiome and how it affects susceptibility to HIV and cervical cancer disease progression in women. These are well-powered prospective clinical cohort studies with thousands of clinical biospecimens available to study host-microbiome relationships. This position will join a diverse international team and provide the opportunity to travel and work with clinician researchers and partner institutions, including those in Spain, Africa, Canada and the United States. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants.

The Center for Global Health and Diseases (CGHD) at CWRU has well over 35 years of experience in initiating, managing and successfully training early career scientists. The department specializes in viral epidemiology, immunology, host genetics, microbiome, systems biology, and public health. The collective group includes many principal investigators, post-docs, graduate students, and technical/support staff. The applicant will join a large diverse team of research groups located at the Center for Global Health and Diseases, as well as our partner laboratory located at the University of Manitoba, Canada (www.burgenerlab.ca).

Applicants should submit a cover letter, CV, and names of three references to (electronic submissions only please):

Dr. Adam Burgener

Center for Global Health and Diseases

Case Western Reserve University

adam.burgener@case.edu

and cc Dennis Dobbs at dennis.dobbs@case.edu

Please indicate which research area you are applying (metagenomics or proteomics/metabolomics).

Review of applications will begin on a rolling basis and continue until the positions are filled.

Apply with CV and Cover Letter

Must be a .doc, .docx, or .pdf file and no larger than 1MBMust be a .doc, .docx, or .pdf file and no larger than 1MB
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Post-doctoral positions in multi-‘omic studies of the microbiome in HIV & Cancer