How does liquid phase separation regulate gene expression and nuclear organization?
What is the biological function of fat storage inside the nucleus?
How are gigantic nuclear pores inserted into the nuclear envelope?
Each of these questions addresses important contemporary puzzles in biology. Our goal is to shed light on these problems to understand the basic principles of how eukaryotic cells protect, decode and regulate their genome. We combine biochemical reconstitution with structural, proteomic and genetic studies as well as high-resolution microscopy, to fuel our search for fundamental discoveries. Projects are available in all of the aforementioned areas and beyond.
Examples of our work: Gallego et al. NATURE, 2020; Romanauska & Koehler CELL, 2018; Schneider et al. CELL, 2015.
We are looking for energetic, creative, quantitatively-minded and interdisciplinary scientists, who want to solve challenging problems with us. You should have obtained your PhD recently or expect to complete your PhD soon. A demonstrated scientific excellence with at least one strong published or upcoming first author paper is required.
The Koehler lab provides a stimulating environment for successful scientific work with minimal technological or financial obstacles. The Max Perutz Labs (https://www.maxperutzlabs.ac.at) are located at the Vienna Biocenter Campus (http://viennabiocenter.org), a leading biomedical research location in central Europe.
You will benefit from a range of excellent core facilities (http://www.vbcf.ac.at/home/). The institute is home to scientists from over 40 different nations with English as the working language. Vienna was named as city with highest quality of life in the world for the tenth time in a row in 2019 (Mercer survey). Childcare facilities are available on campus.
The position is endowed with a competitive salary and is available initially for 3 years. It may be turned into a permanent position depending on performance. Lab funding includes an ERC Consolidator Grant and a NOMIS Pioneering Research Grant.
Please submit your CV, a statement of research accomplishments and future goals and
and arrange to have three letters of recommendation sent as well. Shortlisted candidates will be contacted via email. The positions are open immediately.
Send correspondence to: Prof. Alwin Koehler – Scientific Director
For more information see our website at: https://www.mfpl.ac.at/groups/mfpl-group/group-info/koehler-alwin.html