The University of Texas MD Anderson Cancer Center

Postdoctoral Positions in cancer functional genomics and therapeutic development.

The University of Texas MD Anderson Cancer Center

Houston, TX, United States

Postdoctoral Positions in cancer functional genomics and therapeutic development

Two postdoctoral positions are available in the laboratory of Yonathan Lissanu Deribe, M.D, Ph.D., in the Department of Cardiovascular and Thoracic Surgery at The University of Texas MD Anderson Cancer Center with joint appointment in the Department of Genomic Medicine. Our lab focuses on understanding the role of chromatin biology in cancer development, identifying genetic vulnerabilities of cancers and development of novel cancer therapeutics (Lissanu Deribe et al Nature Medicine 2018, Lissanu Deribe et al PNAS 2016).

To this end, we utilize genetically engineered mouse (GEM) models of cancer, various functional genomic approaches including genome-wide CRISPR knockout screens and epigenomic technologies such as high-throughput RNA- and ChIP-Seq and ATAC-Seq.

We plan to expand our efforts in identifying novel therapeutic targets in genetically defined tumors. Recently, we have discovered novel proteolysis targeting chimeric molecules (PROTACs) that induce selective degradation of oncoproteins and won several grants to further develop these molecules as therapies.

Both positions will provide deep exposure and training in cancer genetics, chromatin biology, functional genomics and cancer therapeutic development.

We seek highly motivated individuals with a Ph.D. or equivalent degree in all areas of molecular & cell biology, biochemistry or genetics. Candidates with training in statistics or programming expertise, in particular R/Python and interest in the application of state-of-the-art computational/statistical methods to complex data are particularly encouraged to apply. Experience with hands on mice work is a big plus but not required.

The Lissanu laboratory is situated in a highly dynamic and stimulatory environment for learning. MD Anderson Cancer Center is rated number one hospital in cancer care in the United States. The institute offers active graduate and postdoctoral training programs and the unmatched scientific environment of the Texas Medical Center, the world’s largest biomedical center. Competitive salary and benefits are provided to post-doctoral fellows. Houston is the fourth largest city in the USA with a vibrant and booming economy. Houston has a mild winters and is sunny year round.

Responsibilities:

• Use cutting-edge approaches to seek novel therapeutic targets for human cancers

• Be responsible for the design and execution of experimental work, data analysis and write up

• Attend and present at internal and international meetings

• Be expected to publish data in top scientific journals

Job requirements:

• PhD or equivalent in Molecular Biology, Biochemistry, Genetics or related field

• Good publication record

• Excellent communication skills is required.

Please send a cover letter, curriculum vitae, names and contact information of three references, and a brief summary of past research accomplishments and future research plans to: Yonathan Lissanu Deribe, M.D, Ph.D. (ylissanu@mdanderson.org)

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Postdoctoral Positions in cancer functional genomics and therapeutic development.