University of Pittsburgh School of Medicine (UPSOM)

Post-doctoral positions in brain tumor biology and immunology

University of Pittsburgh School of Medicine

Pittsburgh, PA, United States

The Kohanbash and Hu Labs in the Department of Neurological Surgery, University of Pittsburgh School of Medicine and UPMC Children’s Hospital of Pittsburgh are seeking several highly motivated and skilled post-doctoral candidates who have a solid background either in tumor immunology or cancer biology.

The Kohanbash Lab (http://www.neurosurgery.pitt.edu/research/pnio-lab) is focused on brain cancer immunology including the following projects:

  1. Development and testing of immunoPET tracers.
  2. Single-cell RNAseq (scRNA seq) to identify and validate T cell receptor (TCR) for development of adoptive cell transfer (ACT) trial.
  3. Identification of neoantigens in pediatric brain tumors.
  4. Pre-clinical testing of immunomodulatory compounds.

The Hu Lab (http://www.neurosurgery.pitt.edu/research/brain-tumor-evolution-therapy-lab) is interested in the genetic and epigenetic mechanisms involved in the evolution of brain tumors, including:

  1. Developing sophisticated models to understand tumor development, progression and treatment resistance.
  2. Elucidating cancer cell-intrinsic signaling communicating with tumor microenvironment.
  3. Illuminating mechanisms governing cancer cells invasion and dissemination in brain.

Our well-funded and diverse laboratories are dynamic and motivating environments for scientific growth and development of independent academic careers. Candidates will be encouraged to develop their own ideas in a fun and collaborative setting. Our recent research can be found in the publications (Muller et al., JCI Insight 2018; Chheda et al., J Exp Med 2018; Kohanbash et al., J Clin Invest 2017; Hu et al., Cell 2016; Wang et al., Cancer Cell 2017; Ong et al., PNAS 2017).

Requirements:

  • PhD/MD. with a background in cancer genomics, epigenetics, cancer biology or immunology.
  • Capable of working independently with appropriate supervision on assigned projects as well as in a team.
  • Strong written and verbal skills in English are essential.
  • Individuals with experience in immunology or brain tumor biology will be given preference.
  • Experience in murine cancer models is a plus.
  • Experience with bioinformatics and next-generation sequencing is preferred, but not necessary.
  • Motivated to pursue postdoctoral training required for a future independent academic career.

Candidates who meet the above criteria are encouraged to apply. Please email a detailed CV, cover letter and contact information for 3 references to Dr. Gary Kohanbash (gary.kohanbash2@chp.edu) and Dr. Baoli Hu (baoli.hu3@chp.edu).

The University of Pittsburgh School of Medicine is ranked as one of the fifteen best schools of medicine in research. Our labs are affiliated with UPMC Hillman Cancer Center, an NCI-designated Comprehensive Cancer Center with 344 members; 10 research programs in basic, translational, clinical, and population sciences. University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center (UPMC) provide the world-class training environment for researchers and clinicians. 

The University of Pittsburgh is an EEO/AA/M/F/Vets/Disabled Employer.

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Post-doctoral positions in brain tumor biology and immunology