Joint recruitment by:
Prof. Peter Carmeliet, MD, PhD
Laboratory of Angiogenesis & Vascular Metabolism, VIB Center for Cancer Biology (CCB)
VIB, KULeuven, Department of Oncology, Leuven, Belgium
Prof. Xuri Li, PhD
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center
Sun Yat-Sen University, Guangdong, P. R. China
Dr. Peter Carmeliet’s laboratory is at the Center for Cancer Biology, VIB, KU Leuven, Campus Gasthuisberg. The lab is focusing on angiogenesis and vascular metabolism in health and disease with the ultimate aim to identify novel therapeutic strategies. The laboratory is using transcriptomics and genomics strategies (including bulk and single-cell RNA-sequencing, shallow sequencing, single-cell genome & transcriptome sequencing, whole exome sequencing, whole genome sequencing and epigenomics) in combination with bioinformatics analysis to characterize the genome/transcriptome landscape of vascular endothelial cells. Recent genomics and transcriptomics projects of the lab revealed unexpected, novel insights in perturbed cytogenetic features of endothelial cells in pathological conditions. The lab is further investigating these findings, focusing on unraveling the mechanisms of these genomic aberrations, the cellular heterogeneity and its role in disease.
Dr. Xuri Li’s laboratory (http://www.zocangio.org/) is at the State Key Laboratory of Ophthalmology (SKLO, http://sklo.gzzoc.com/administration/office/), Zhongshan Ophthalmic Center (ZOC), Sun Yat-sen University (SYSU) in Guangzhou, China. SKLO is the only one of its kind in China and is supported by the central Chinese government. ZOC is the all-time number one eye hospital in China. SKLO and ZOC together constitute the largest eye care and research center in the world. SYSU is the 2nd top-ranked university in China in terms of the numbers of top 1% research disciplines in the world and campus area in China. Before joining SKLO/ZOC, Dr. Xuri Li served as a Principal Investigator at the NIH/NEI in the US for seven years and is the founder of Asia Pacific Vascular Biology Organization (APVBO, http://www.apvbo.org/html/Mission_Statement.html). Dr. Li’s laboratory studies angiogenesis, metabolism of vascular cells, neovascular ocular diseases, stem cells and ocular tumors.
Dr. Peter Carmeliet and Dr. Xuri Li are jointly recruiting postdoctoral fellows in bioinformatics/vascular biology. Successful candidates will use the above mentioned state-of-art genetic technologies to characterize the DNA/RNA landscape of vascular endothelial cells from human/mouse neovascular diseases or cancers to identify changes of genes during disease progression for anti-angiogenic treatment, and to gain mechanistic insight into such genetic changes.
• Working independently within a multidisciplinary team to bring complementary expertise in the analysis of the genomic aberrations of vascular endothelial cells and vascular biology
• Contribute to projects analyzing the RNA/DNA landscape of vascular endothelial cells by applying the above mentioned genetic and vascular biology technologies
• Wet- and dry-lab expertise in (quantitative) genetics, genomics, vascular biology, and/or molecular biology and tailoring these towards specific research questions
• Organizing and troubleshooting practical work independently
• Communicating results in a professional manner in English
• Participating in high-level seminars in English
• Work in both Prof. Peter Carmeliet’s laboratory in Leuven, Belgium and Prof. Xuri Li’s laboratory in Guangzhou, China
• Proficient in English
• A competitive remuneration package commensurate with experience/qualifications, annual salary starting from 300,000 RMB (about 43,000 USD)
• Long-term career opportunities
• Access to state-of-the-art technologies in biomedical research
• Excellent training conditions within a team of top experts
• The opportunity to work in a multidisciplinary international team and contribute to the generation and biological validation of genomics data sets
• A dynamic working environment in which quality, professionalism and team spirit are encouraged
• Dr. Peter Carmeliet’s lab is situated in Leuven, a charming and vibrant university city, and only a stone’s throw away from the cosmopolitan city of Brussels at the heart of Europe.
• Dr. Xuri Li’s lab is located in Guangzhou, the third largest city on the southern coastline of China. Being a close neighbor of Hong Kong and Macau, Guangzhou is the commercial, scientific, educational and cultural center of Southern China.
• Starting as soon as possible.
• Candidates have a PhD in bioinformatics, genetics, genomics, genome instability, DNA repair, vascular biology, molecular biology, or related fields.
• Candidates are interested in analyzing and integrating complex omics- and clinical datasets, and in working in a multidisciplinary environment of experts in biomedical sciences, transcriptomics, genomics and bioinformatics.
• Experience in next-generation sequencing and computational genomics
• Have strong data analytical skills and a fundamental knowledge of bioinformatics (R, Python, programming skills, machine learning) and previous experience in analyzing high-throughput data.
• Candidates are interested and motivated to work on ambitious projects in an open, dynamic, competitive and driven team.
• You should have excellent organizational and supervisory skills, and can work in a team as well as independently.
• Have a strong ability to multi-task, meet timelines and work accurately.
• Proficient communication skills in spoken and written English
• Have a good publication record (including at least one paper as a first author) in peer-reviewed international journals, with an emphasis on quality rather than quantity of publications.
• Complete CV
• Motivation letter
• List of publications
• Summary of past research
• Contact information or reference letters of 2 or 3 referees (or, provide them upon request)