University of Pittsburgh (Pitt)

Post-Doctoral Position

University of Pittsburgh Drug Discover Institute

Pittsburgh, PA, United States

Post-Doctoral Position in Human Liver Microphysiology Systems (MPS) In the laboratory of D. Lansing Taylor, Ph.D., Director, University of Pittsburgh Drug Discovery Institute (UPDDI) Distinguished Professor and Allegheny Foundation Professor of Computational and Systems Biology

Start Date: September 2019
Funding from NIH-NCATS, the EPA, and NIH-NIDDK, NIH-CTSA

Job Description:
UPDDI is searching for a Postdoctoral Fellow to apply a human liver Microphysiology System (MPS) for the development and analysis of human, 3D cellular models of liver diseases using both primary human cells and iPSC-derived cells. Experience with 3D, MPS biological models preferred. In addition, expertise in the liver, use of fluorescence imaging microscopy of cellular systems is preferred. This is an excellent opportunity to get involved in a series of high profile collaborations in developing and applying microfluidic organ models for disease and toxicology testing.

Position Responsibilities:
• Characterize the structure and functions of a human, 4 cell-type, liver disease MPS including non-alcoholic fatty liver disease and/or type 2 diabetes over one month based on primary human cells and iPSC-derived cells
• Collaborate with colleagues to incorporate fluorescence-based biosensors into one or more cell types
• Collaborate with colleagues to integrate the human liver MPS with other organ MPS including pancreatic islets, white adipose tissue, intestine
• Plan and execute experiments, analyze and present results in presentations and publications
• Collaborate with the liver microphysiology systems team and clinician-scientists at Pitt

Experience and Training:
• Ph.D in physiology, pathology, cell biology, biophysics, biomedical engineering, or related field
• Experience in liver cell and organ physiology, cell biology and molecular biology
• Experience in using automated imaging systems preferred
• Experience with primary human cells and iPSCs a plus.

Applicants are invited to send their CV, and names of two references (or reference letters) to: cmg72@pitt.edu Christine M Grabowski, Administrator
The University of Pittsburgh is an Affirmative Action, Equal Opportunity Employer

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Position

Post-Doctoral Position