Cluster of Excellence - Werner Reichardt Centre for Integrative Neuroscience (CIN), Uni Tübingen

Post-doctoral position (Neurobiology, Molecular biology, Microscopy, Protein labelling/engineering)

Werner Reichardt Centre for Integrative Neuroscience (CIN), Laboratory of Ivana Nikic-Spiegel

Tübingen, Germany

We are looking for a post-doctoral fellow to join our laboratory at the Werner Reichardt Centre for Integrative Neuroscience (CIN) in Tübingen.

Our lab studies factors regulating axonal stability and breakdown. We previously described focal axonal degeneration, a novel form of axonal injury in a mouse model of a common neuroinflammatory disease, multiple sclerosis (Nikić et al, Nature Medicine 2011). We study the mechanisms of axonal injury in vitro, at the level of single cells, and in vivo in animal models.

In addition to more standard fluorescence microscopy techniques, we use super-resolution microscopy, such as stochastic optical reconstruction microscopy (STORM). We combine STORM imaging with our recently developed live cell protein labelling technique. Our labelling approach is based on selective incorporation of unnatural amino acids (Nikić et al., Angewandte Chemie 2014; Nikić, Kang, Girona et al., Nature Protocols 2015; Nikić & Lemke, Current Opinion in Chemical Biology 2016; Nikić et al., Angewandte Chemie 2016). With unnatural amino acids, new properties (functional groups), such as fluorescent dyes, affinity tags for proteomics, post-translation modifications, cross-linkers, optogenetic groups, etc. can be introduced into proteins at a single cell and even whole organism level.  

The selected candidate will contribute to the ongoing projects in the lab, but is also expected and will be encouraged to develop their own ideas. Considering the interdisciplinary nature of our work, in addition to the researchers with a PhD in neuroscience, we also encourage researchers from other fields (Molecular/Chemical Biology, Physics, Biochemistry, etc.) to apply. Previous experience with microscopy/image processing, molecular biology/genetic engineering techniques, animal models, microfluidics, or proteomics will be of advantage, but the most important criteria for selection are motivation, curiosity, a willingness to become a supportive team member, and fluency in English.

Desired start date is as soon as possible. Interested applicants should provide one pdf file containing a CV, a cover letter describing research experience and future interests, and contact details of 2-3 referees by E-Mail to: ivana.nikic@uni-tuebingen.de.

The position will be open until filled.

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Position

Post-doctoral position (Neurobiology, Molecular biology, Microscopy, Protein labelling/engineering)