BioMed X Innovation Center

Postdoctoral Position (m/f/d) Intestinal Epithelial Barrier in Autoimmune Diseases

BioMed X Institute

Heidelberg, Germany

About BioMed X

BioMed X is an independent research institute located on the campus of the University of Heidelberg in Germany. Together with our partners, we identify big biomedical research challenges and provide creative solutions by combining global crowdsourcing with local incubation of the world’s brightest early-career research talents. Each of the highly diverse research teams at BioMed X has access to state-of-the-art research infrastructure and is continuously guided by experienced mentors from academia and industry. At BioMed X, we combine the best of two worlds – academia and industry – and enable breakthrough innovation by making biomedical research more efficient, more agile, and more fun.

About Team Intestinal Epithelial Barrier in Autoimmune Diseases (IEB) The main objective of the group, headed by Dr. Martin Resnik-Docampo, is to understand the molecular mechanisms of the interactions between intestinal epithelial barrier and immune cells, in particular the interactions between dendritic cells and intestinal enterocytes. Studies will involve use of conventional and high-throughput metagenomics, generation of intestinal organoids from murine and human subjects, isolation of immune cells and co-culture system  Our final goal is to identify novel biomarkers and develop new therapeutic targets for intestinal barrier loss and autoimmune diseases that will improve patient outcomes.

The Position For the open postdoc position in Team IEB, we are looking for highly enthusiastic researchers to broaden our think-tank with their intellectual power and technical excellence. The ideal candidate would have a Ph. D degree in cell/molecular biology, immunology or biochemistry and a strong background in immunology.

Required skills

  • Proven experience in generation and culture of intestinal organoids
  • Proven experience in the Intestinal Barrier field 
  • Experience in histology procedures
  • Experience with animal work / willing to work with animals 
  • Experience with high-throughput screening techniques (i.e. RNAseq)
  • Experience with microscopy techniques (e.g. confocal microscopy, live cell imaging) 
  • Skills in basic biochemistry techniques (e.g. ELISA, immunoblotting)
  • Skills in bioinformatic analysis 
  • Independent thinking
  • Experienced to work in interdisciplinary teams
  • Excellent communication skills in English

  Additional preferred skills

  • Theoretical and/or technical background in immunology and autoimmune diseases
  • Proven Experience in immune profiling (Flow cytometry)
  • Experience with high-resolution imaging platforms and mass cytometry (CyTOF) or mass spectrometry.
  • Familiarity with basic molecular biology techniques and genetic manipulation of cells (e.g. RNA isolation, cloning, lentivirus preparation, transduction, overexpression and knockdown, CRISPR/Cas9)

  Candidates are requested to submit

  • 1-page cover letter explaining the reasons of interest to join our team * Curriculum Vitae outlining scientific interests, research achievements, a record of publications, future personal goals and extra-scientific passions
  • 2 reference letters

What we offer The post is offered for a limited term until 31 October 2023.

  • International, diverse, and positive work atmosphere,  flexible working environment
  • A competitive salary 
  • Access to training and lecture courses in house as well as in neighboring research institutions on the Life Science Campus in Heidelberg 
  • Access to a vast scientific network. 
  • Job ticket, sponsored fitness contract, complimentary fresh fruit, soft drinks and chocolate team recognition events, etc.

The position is available as of 1 September 2020 and is sponsored by Merck.  Please submit your application to the attention of Dr. Martin Resnik-Docampo before 21 July 2020 via our online application system: https://apply.bio.mx/job/2020-J04. Applicants will be interviewed upon incoming documents, hence please get in touch as soon as you decide to apply.

  Contact BioMed X Institute Im Neuenheimer Feld 515 69120 Heidelberg, Germany Email: resnik@bio.mx Internet: www.bio.mx

Please apply via recruiter’s website.

Quote Reference: 2020-J04