Howard Hughes Medical Institute (HHMI)

Postdoctoral Position - Martin Lab

Howard Hughes Medical Institute (HHMI)

Berkeley, United States

The Martin Lab at UC Berkeley is looking for a postdoc with strong expertise in biochemistry to address exciting questions about the mechanisms of protein quality control, ATP-dependent protein degradation, and the ubiquitin-proteasome system.

The successful candidate will work on a research program focusing on the 26S proteasome and related protein translocases of the AAA+ ATPase family, and investigate general ATPase motor function, ubiquitin-dependent substrate recognition/selection, and the principles of mechanical protein unfolding on the surface of ring-shaped ATPases.


In addition to a solid background in biochemistry, experience in structural biology, single-molecule manipulations, mass spectrometry, or cell biology would be beneficial, but is not required.


Preferred Qualifications:

  • Ph.D. in Biochemistry, Biophysics, or a related field, with a track record of publication in peer-reviewed journals.


Expertise In One Or More Of The Following Areas:

  • In vitro biochemistry, enzyme kinetics
  • Recombinant protein expression and purification
  • Protein fluorescence and absorbance measurements
  • Single-molecule TIRF microscopy or force measurements (tweezers, fleezers)
  • Mass spectrometry
  • Structural biology (X-ray crystallography or cryo-EM)
  • Cell biology
  • Demonstrated ability to work independently
  • Excellent oral and written communication skills


To apply, please submit a single pdf that includes

  • A cover letter describing your research and career goals, and your expertise in biochemistry or structure-function studies
  • A curriculum vitae, including a list of publications with brief (2-3 sentence) descriptions of your contributions to the published work
  • Contact information for 3-5 references


Please send your application to Andy Martin at


HHMI is an equal opportunity employer.

Please apply via recruiter’s website.

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