The Stutz lab has long-standing experience in mRNA biogenesis and export through nuclear pores, the importance of nuclear organization in gene expression, as well as the influence of non-coding transcription on gene expression and replication using the yeast S. cerevisiaeas a model system.
More recent work addresses the mechanisms by which the cell eliminates DNA-protein crosslinks (DPCs) induced by UV irradiation or genotoxic drugs to maintain genome integrity. Through genetic screens we have identified a novel protease and alternative repair pathways activated in response to replication stress or RNA polymerase stalling induced by DPCs (https://doi.org/10.1101/575860).
The current research project aims at characterizing the targets of this evolutionarily conserved protease and defining the co-factors and molecular mechanisms through which it eliminates the DPCs. These studies may also be relevant to human cancer research as treatment with certain drugs that induce DPCs may result in resistance due to the activation of the studied alternative repair pathways.
The successful candidate will have:
- Excellent qualifications with a PhD in Molecular Biology, Biochemistry or Cell Biology.
- A special interest in the field of transcription/DNA replication/genome stability; expertise with yeast genetics, proteomics and cell-based imaging will be an asset.
- Fluent spoken and written English, good organizational, communication and interpersonal skills.
- Successfully finalized a previous project as first author, already published or in advanced consideration in a peer reviewed journal.
Only candidates currently residing in Europe will be considered for this position. The appointment is initially for one year and may be renewed for up to 3 years. The position is available right away.
Please send your application as a single pdf-file including a letter of motivation and research interests, a comprehensive CV and contact details for 2 references to Francoise.Stutz@unige.ch.