Bioingénierie Tissulaire (BioTis)

Postdoctoral position in Vascular Tissue Engineering

BioTis - Bioengineering of Tissues

Bordeaux, France

The Lab:

Our lab is part of BioTis (Bioengineering of Tissues), the research “unit” 1026 of the INSERM, embedded in the University of Bordeaux. The work of my team is centered around the use of Cell-Assembled extracellular Matrix (CAM), which is produced by cells in long-term cultures. More specifically, my group focuses on vascular applications and specifically on the development of a small diameter tissue-engineered vascular graft (TEVG). I have just received an “ERC advanced” grant (5 year, 2.5M€), which will allow our team to grow significantly, and will be leverage to develop a long-term vascular tissue engineering effort in Bordeaux.

The Project:

Your work will be to produce TEVG by weaving threads produced from CAM. The project involves identifying how the TEVG properties are affected by assembly variables (thread type, weaving patterns, etc.). The project will look at optimizing the TEVG design using human and ovine CAM. Ultimately, allogeneic ovine TEVG will be implanted for long-term follow-up. The project is on-going and involves two PhD students and staff. Projects may be added or modified depending on progress and duration of the post-doc.

The Job:

  • Designing and conducting experiments (cell culture, weaving, implantation/biopsy retrieval in animals, mechanical testing, histology, imaging, etc.).
  • Participating in laboratory activities (ordering, maintenance, organization, etc.).
  • Work with and supervise graduate students or staff.
  • Writing articles, reports, protocols, grant proposals.
  • Communicating data internally and in scientific meetings.

Requirements:

  • A Ph.D. with a biological component
  • At least one successful post-doc
  • Extensive experience in tissue-engineering with in vivo implantation or extensive experience in vascular in vivo implantation.
  • Excellent publication record.
    • Excellent dexterity
    • Excellent ability to work in groups
    • Good communications skills.
    • Good written English.
    • Experience in cell culture is desirable.
    • Experience in histological techniques is a plus.
    • Experience in mechanical testing is also a plus.
    • Experience in mass spectrometry is an advantage.

The ideal candidate:

  • Candidates with the long-term interest of joining the INSERM, and with a publication record compatible with this ambition, will receive special consideration. This should not discourage other excellent applicants since such candidates are rare.

Notes:

  • The position shall remain open until the position is filled.
  • This is a full time, 1 year, postdoctoral appointment with the possibility of multiple renewals based upon satisfactory job performance, continuing availability of funds (5 years available at this time) and ongoing operational needs.
  • Salary will be determined based on years of experience post-degree according to established institution guide lines. Benefits included according to INSERM guidelines.

Candidates should send a motivation letter, their CV and the names of 3 references to Nicolas L’Heureux at nicolas.lheureux@inserm.fr with the subject line POSTDOCTORAL POSITION 2019.

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Position

Postdoctoral position in Vascular Tissue Engineering