Cancer Research Center of Lyon (CRCL)

Post-doctoral position in the field of stem cell pluripotency, reprogramming and cancer biology

Cancer Research Center of Lyon (CRCL)

Lyon, France

A post-doctoral position is available in the laboratory of Fabrice Lavial at the Cancer research center of Lyon (CRCL). The main lab interests are centered on the control of stem cell pluripotency, cellular reprogramming and oncogenesis both in vitro and in vivo. The post-doc to be recruited will join a project addressing the function of candidates in stem cell pluripotency, mouse pre-implantation development and somatic cell reprogramming.

Potential candidates should hold (or be about to obtain) a PhD and must be able to conduct their research independently. Expertise in embryonic/induced pluripotent stem cells, signalling and/or early embryos is a plus.

Funding is provided for 18 months, extendable. The starting date is not firmly fixed, but should be preferentially set within the year 2020.

Candidates should send their application (including letter of motivation, CV and referees contact) to fabrice.lavial@lyon.unicancer.fr

For more detailed information, please find below selected publications related to the project:

1- Ozmadenci D., Feraud O., Markossian S., Kress E., Ducarouge B., Gibert B., Jeng G., Durand I., Gadot N., Scoazec JY., Bennaceur-Griscelli L., Plateroti M., Gil J., Deng H., Bernet A., Mehlen P. and Lavial F. Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance.
Nature Communications 6:7398, 2015.

2-Puisieux A., Pommier R., Morel A.P. and Lavial F.
Cellular pliancy and the multistep process of tumorigenesis.
Cancer Cell 33:164-172, 2018.

3- Huyghe A., Furlan G., Ozmadenci D., Galonska C., Charlton J., Gaume X., Combémorel N., Riemenschneider C., Allègre N., Zhang J., Wajda P., Rama N., Vieugué P., Durand I., Brevet M., Gadot N., Imhof T., Merrill B., Koch M., Mehlen P., Chazaud C., Meissner A. and Lavial F.
Netrin-1 promotes naïve pluripotency through Neo1 and Unc5b co-regulation of Wnt and Mapk signalling.
Nature Cell Biology, accepted in principle.

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Position

Post-doctoral position in the field of stem cell pluripotency, reprogramming and cancer biology