Washington University in St. Louis (WUSTL)


Washington University in St. Louis (WUSTL)

St Louis, MO, United States

FULLY FUNDED POSTDOCTORAL POSITIONS focusing on mechanisms of synaptic transmission and their dysregulation in Fragile X syndrome and Alzheimer’s disease are available in the laboratory of Dr. Vitaly Klyachko at Washington University School of Medicine.

This is a unique opportunity to engage in cutting-edge research fully supported by an 8-year R35/MIRA NIH award.

We build and utilize advanced biophysical approaches, including multicolor 2D and 3D super-resolution imaging, electrophysiology and computational tools to study the mechanisms governing synaptic transmission and excitability in healthy neurons (Maschi et al, eLife 2018, Neuron 2017, Gramlich et al Cell Reports 2017, Peng et al Neuron 2012) and their dysregulation in Fragile X syndrome, the leading known genetic cause of autism (Deng et al, J Neurosci 2019, Cell Reports 2016, Neuron 2013, Myrick at al, PNAS USA 2015). We have also recently expanded our efforts towards understanding synaptic dysfunction in Alzheimer’s disease with the particular focus on the role of glia in this disorder.

Qualified applicants are expected to hold a doctoral degree in life sciences, physics or engineering. Applicants with expertise in advanced imaging tools/nanoscopy or cellular electrophysiology as well as knowledge of Matlab are particularly encouraged to apply.  

Trainees will work in a highly interactive multidisciplinary research environment at Washington University, which has been consistently ranked among the top five Medical Schools in the country. The extreme collegiality of Washington University combined with the large Neuroscience Community and extensive infrastructural and core facility support creates a dynamic research environment. Highly competitive salary and benefits are available and will commensurate with experience. Complete information on the benefit package is located on the WUSM Human Resources Benefits Website (http://medschoolhr.wustl.edu). The St. Louis area combines the attractions of a major city with family-friendly and affordable lifestyle opportunities (http://www.stlouis.com/).

Interested applicants should provide their CV and the names of two or three references via email to:

Vitaly Klyachko, PhD                                                                                     


Department of Cell Biology and Physiology

Washington University School of Medicine                                                         

Phone: (314)362-5517

E-mail: klyachko@wustl.edu

Apply with CV and Cover Letter

Must be a .doc, .docx, or .pdf file and no larger than 1MBMust be a .doc, .docx, or .pdf file and no larger than 1MB