A 3-year postdoctoral position is open in the lab of Prof. Beat Schäfer at the University Children’s Hospital Zurich to study the biology of the oncogenic fusion transcription factor PAX3-FOXO1 in Rhabdomyosarcoma and to develop novel compounds targeting this seemingly “undruggable” therapeutic target. Our laboratory studies the biology of Rhabdomyosarcoma development since more than 10 years (Wachtel and Schäfer, Semin Cancer Biol 2017; Gryder al. Cancer Discov 2017; Böhm et al J Clin. Invest 2016; Satheesha et al Oncogene 2016; Thalhammer et al Cancer Res 2015) and is specifically interested in fusion transcription factors and tumor cell heterogeneity.
The postdoctoral fellowship is available immediately and funded through a U54 collaborative research network by the NCI (see: https://www.cancer.gov/research/key-initiatives/moonshot-cancer-initiative/implementation/childhood-cancer-research). The position offers extensive interaction with a network of US-based laboratories to promote the development and validation of novel small molecules from microarray screens targeting PAX3-FOXO1. Identified binders will be further developed into PROTACs and validated in primary RMS cells as well as established cell lines. Travel and networking will be an important part of the position.
Applicants must hold a PhD in cancer biology or in a related field and have a strong background in biochemistry, molecular and cellular biology, and bioinformatics. Previous experience in translational research including drug development, in vivo mouse experiments, and genome-wide screens will be important. An exceptionally strong commitment to science and motivation are prerequisites. Candidates should be able to travel to Zurich for the interview process.
The University of Zurich offers a large range of state-of-the-art laboratories including service centers for flow cytometry, microscopy and genomic studies (proteomics and transcriptomics). We also offer highly competitive postdoctoral salaries (~CHF 80’000 per year).
For further inquiries please contact Beat Schäfer at firstname.lastname@example.org
Complete applications should include a brief description of research experiences, a statement regarding future career plans, curriculum vitae and the names of two references and should be sent to email@example.com.